2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel
  5. TRPA1 Isoform
  6. TRPA1 Antagonist

TRPA1 Antagonist

TRPA1 Antagonists (7):

Cat. No. Product Name Effect Purity
  • HY-120689
    PF-04745637
    		Antagonist 99.97%
    PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1.
  • HY-15058
    AMG2504
    		Antagonist
    AMG2504 is a TRPA1 antagonist with an IC50 value of 35 nM against human TRPA1. AMG2504 inhibits human TRPA1 activation induced by AITC and noxious cold stimulation. AMG2504 is applicable to research related to chronic pain.
  • HY-15065
    Chembridge-5861528
    		Antagonist 99.12%
    Chembridge-5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. Chembridge-5861528 shows antihypersensitivity activities.
  • HY-172774
    TRPV1 antagonist 10
    		Antagonist 98.54%
    TRPV1 antagonist 10 is an orally active and potent TRPV1 antagonist (IC50 = 33.06 nM), moderate to weak URAT1 (IC50 = 22.51 μM) and GLUT9 (60.25% at 50 μM) inhibitor. TRPV1 antagonist 10 has analgesic and urate-lowering effect. TRPV1 antagonist 10 can be studied for research in hyperuricemia and inflammatory pain.
  • HY-115877
    GDC-0334
    		Antagonist
    GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma.
  • HY-104061
    AMG8788
    		Antagonist
    AMG8788 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 63.2 nM.
  • HY-104062
    AMG9678
    		Antagonist
    AMG9678 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 31.2 nM.