ClpP
Caseinolytic protease P
Caseinolytic protease P (ClpP) is a mitochondrial serine protease. In mammalian cells, the heterodimerization of ClpP and its AAA+ ClpX chaperone results in a complex called ClpXP, which has a relevant role in protein homeostasis and in maintaining mitochondrial functionality through the degradation of mitochondrial misfolded or damaged proteins.
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ClpP Related Products (36)
Related Products (36)
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Pan-PDK degrader-1
0 ImagesCat. No.: HY-184943Pan-PDK degrader-1 is a pan-PDK class PROTAC degrader that degrades PDK2, PDK3 and PDK4 with DC50 values of 9.2 nM, 9.9 nM and 11.5 nM, respectively. Pan-PDK degrader-1 recruits the mitochondrial protease HsClpP and induces selective pan-PDK degradation via HsClpP-mediated proteolysis. Pan-PDK degrader-1 reprograms mitochondrial metabolism toward oxidative phosphorylation, promoting ROS accumulation, mitochondrial permeability transition pore opening, endogenous mitochondrial apoptosis, calreticulin exposure and HMGB1 release. Pan-PDK degrader-1 upregulates cleaved Caspase-9, Caspase-3 and PARP. Pan-PDK degrader-1 inhibits primary and distal tumor growth via selective degradation of PDK in tumor tissues. Pan-PDK degrader-1 can be used for the research of breast cancer.
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ZG36
0 ImagesCat. No.: HY-155556CAS No.: 2999673-34-4ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model.
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ADEP-14
0 ImagesSynonyms: ADEP26ADEP-14 (ADEP26) is a ClpP activator. ADEP-14 exhibits antibacterial activity against Gram-negative and Gram-positive bacteria. ADEP-14 can be used in studies related to bacterial infections.
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HsClpP activator-1
0 ImagesCat. No.: HY-176427CAS No.: 3087033-83-5HsClpP activator-1 (compound 24) is a potent HsClpP activator with an EC50 of 0.22 μM. HsClpP activator-1 effectively inhibits cancer cell growth with IC50 values of 0.1-1 μM.
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Z-Gly-Gly-Leu-AMC
0 ImagesCat. No.: HY-P4399CAS No.: 97792-39-7Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu.
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ClpP1P2-IN-1
0 ImagesCat. No.: HY-187235CAS No.: 3069900-75-7ClpP1P2-IN-1 is a protease inhibitor targeting ClpP1P2 of Mycobacterium tuberculosis, with a Ki value of 0.04 μM. ClpP1P2-IN-1 inhibits the growth of Mycobacterium tuberculosis and shows low cytotoxicity against mammalian kidney cells. ClpP1P2-IN-1 can be used in the research of tuberculosis.
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ClpP agonist 1
0 ImagesCat. No.: HY-182033CAS No.: 2761081-10-9ClpP agonist 1 is a Staphylococcus aureus ClpP (SaClpP) agonist with an EC50 of 1.44 μM, Kd values of 2.95 μM (isothermal titration calorimetry) and 18 μM (bio-layer interferometry), and a low drug resistance frequency. ClpP agonist 1 reduces bacterial load, shrinks infected area and improves histopathological outcomes in a mouse skin infection model. ClpP agonist 1 can be used for the research of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) skin infections.
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ZY36
0 ImagesCat. No.: HY-186107ZY36 is a SaClpP agonist with an EC50 of 1.01 μM against Staphylococcus aureus. ZY36 activates SaClpP-mediated proteolysis. ZY36 inhibits the growth of Staphylococcus aureus. ZY36 is applicable to studies related to Staphylococcus aureus infections, such as peritonitis.
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Anti-MRSA agent 39
0 ImagesCat. No.: HY-178912Anti-MRSA agent 39 is an orally active ClpX modulator that binds Staphylococcus aureus caseinolytic protease X (SaClpX) with high affinity (Kd = 3.6 μM). Anti-MRSA agent 39 exerts antibacterial effects through temperature-dependent inhibition of cell division. Anti-MRSA agent 39 elicits profound metabolic dysregulation in methicillin-resistant Staphylococcus aureus (MRSA), manifesting as significantly reduced ATP levels, elevated reactive oxygen species (ROS), and decreased NAD+/NADH ratio, and accelerates bacterial lysis rates in MRSA ATCC 33591. Anti-MRSA agent 39 significantly increases the proportion of MRSA cells in the mitotic phase, and the cells exhibit obvious morphological abnormalities. Anti-MRSA agent 39 can be used for the study of invasive MRSA infections.
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DA29
0 ImagesCat. No.: HY-187371DA29 is a human caseinolytic protease P (hClpP) activator, with an EC50 of 0.85 μM and a Kd of 185 nM. DA29 binds to the hydrophobic allosteric pocket of this enzyme, activates its proteolytic function, and displaces hClpX from the hClpXP complex. DA29 induces mitochondrial dysfunction and ROS accumulation. DA29 exerts cytotoxic effects on cancer cells and organoids. DA29 can be used in the research of diffuse intrinsic pontine glioma.
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ClpP modulator-1
0 ImagesCat. No.: HY-175597CAS No.: 2363753-48-2ClpP modulator-1 (Compound BC8a), a peptidomimetic, is an allosteric ClpP modulator. ClpP modulator-1 is a ClpP activator at low concentration with EC50s of 0.35 and 0.58 μM for for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP), resepectively. ClpP modulator-1 also inhibits peptidase activity at high concentration by competitively inhibiting substrate protein (LY-AMC) binding to ClpP C sites. ClpP modulator-1 has antibacterial activity. ClpP modulator-1 can be used for bacterial infections research.
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ACP1b
0 ImagesCat. No.: HY-126046CAS No.: 1371635-84-5ACP1b is an activator for ClpP protease with Kd of 3.2 μM, and exhibits antibacterial activity. ACP1b inhibits N. meningitidis and H. influenzae with MBC of 16 and 8 μg/mL.
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ZY38
0 ImagesCat. No.: HY-186108ZY38 is a SaClpP agonist that activates SaClpP-mediated α-casein hydrolysis with an EC50 of 1.52 μM. ZY38 exhibits bactericidal activity against Staphylococcus aureus. ZY38 is applicable to studies related to Staphylococcus aureus infections, such as peritonitis.
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Hinokiflavone (Standard)
0 ImagesCat. No.: HY-N2360RCAS No.: 19202-36-9Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity.
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Tamarixetin (Standard)
0 ImagesTamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways.
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ACP1-01
0 ImagesCat. No.: HY-175596CAS No.: 1382489-31-7ACP1-01 is a bacterial ClpP activator with EC50s of 3.4 and 2.6 μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP). ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research.
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