1846579-07-4
Chemical Structure
ADEP-14
Synonym(s): ADEP26
- CAS No.: 1846579-07-4
- Formula:C41H54F2N6O8
- Molecular Weight:796.90
IUPAC Name: (2E,4E)-N-((S)-3-(3,5-difluorophenyl)-1-oxo-1-(((2R,6S,8aS,14aS,20S,21S,23aS)-2,6,21-trimethyl-5,8,14,19,23-pentaoxooctadecahydro-1H,5H,14H,19H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-20-yl)amino)propan-2-yl)octa-2,4-dienamide
InChIKey: HMKPWAZKFGCLHC-FIIDVNKBSA-N
SMILES: [H][C@@]12C[C@H](CN1C([C@@H](NC([C@@]3(CCCCN3C([C@@]4(CCCN4C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/C=C/CCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)[H])=O)C)=O)C
Biological Activity: ADEP-14 (ADEP26) is a ClpP activator. ADEP-14 exhibits antibacterial activity against Gram-negative and Gram-positive bacteria. ADEP-14 can be used in studies related to bacterial infections[1][2].
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ADEP-14 | ADEP-14 (ADEP26) is a ClpP activator. ADEP-14 exhibits antibacterial activity against Gram-negative and Gram-positive bacteria. ADEP-14 can be used in studies related to bacterial infections. | |||||||||||||||||||||
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- [1]. Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025;33(10):1700-1716.e6. [Content Brief]
- [2]. Goodreid JD, et al. Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity. J Med Chem. 2016;59(2):624-646. [Content Brief]
Keywords
