ADEP-14
Based on 1 Customer Validation
ADEP-14 (ADEP26) is a ClpP activator. ADEP-14 exhibits antibacterial activity against Gram-negative and Gram-positive bacteria. ADEP-14 can be used in studies related to bacterial infections.
For research use only. We do not sell to patients.
- Purity : 98.33%
- CAS No.: 1846579-07-4
- Formula: C41H54F2N6O8
- Molecular Weight:796.90
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
ADEP-14 (preincubated for 10 min) potently activates the proteolytic activity of purified Neisseria meningitidis ClpP and Escherichia coli ClpP in casein-FITC degradation assays. It exhibits high binding affinity, and its EC50 value shows a linear correlation with ClpP concentration[1].
ADEP-14 (Compound 26) potently inhibits the growth of wild-type Neisseria meningitidis H44/76 (MIC = 0.0313 μg/mL) and Neisseria gonorrhoeae N.279 (MIC = 0.0078 μg/mL). Its activity depends on functional ClpP, and it exhibits only limited activity against membrane-compromised Escherichia coli strains (MIC = 4 μg/mL)[2].
ADEP-14 potently inhibits the growth of all tested Gram-positive strains, including MRSA (MIC = 0.125 μg/mL) and VRE (MIC = 0.0039 μg/mL); for Streptococcus pneumoniae D39, Bacillus subtilis PY79 and Listeria innocua, its MIC values are ≤0.0625 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1846579-07-4
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Appearance Solid
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Molecular Weight 796.90
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Formula C41H54F2N6O8
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SMILES
[H][C@@]12C[C@H](CN1C([C@@H](NC([C@@]3(CCCCN3C([C@@]4(CCCN4C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/C=C/CCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)[H])=O)C)=O)C
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Synonyms
ADEP26
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 10 mg/mL (12.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025;33(10):1700-1716.e6. [Content Brief]
[2]. Goodreid JD, et al. Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity. J Med Chem. 2016;59(2):624-646. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2549 mL | 6.2743 mL | 12.5486 mL | 31.3716 mL |
| 5 mM | 0.2510 mL | 1.2549 mL | 2.5097 mL | 6.2743 mL | |
| 10 mM | 0.1255 mL | 0.6274 mL | 1.2549 mL | 3.1372 mL |
ADEP-14 Related Classifications
HY-175595 Related Classifications
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