ADEP-14
ADEP-14 (ADEP26) is a ClpP activator. ADEP-14 exhibits antibacterial activity against Gram-negative and Gram-positive bacteria. ADEP-14 can be used in studies related to bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 1846579-07-4
- Formula: C41H54F2N6O8
- Molecular Weight:796.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ADEP-14 (preincubated for 10 min) potently activates the proteolytic activity of purified Neisseria meningitidis ClpP and Escherichia coli ClpP in casein-FITC degradation assays. It exhibits high binding affinity, and its EC50 value shows a linear correlation with ClpP concentration[1].
ADEP-14 (Compound 26) potently inhibits the growth of wild-type Neisseria meningitidis H44/76 (MIC = 0.0313 μg/mL) and Neisseria gonorrhoeae N.279 (MIC = 0.0078 μg/mL). Its activity depends on functional ClpP, and it exhibits only limited activity against membrane-compromised Escherichia coli strains (MIC = 4 μg/mL)[2].
ADEP-14 potently inhibits the growth of all tested Gram-positive strains, including MRSA (MIC = 0.125 μg/mL) and VRE (MIC = 0.0039 μg/mL); for Streptococcus pneumoniae D39, Bacillus subtilis PY79 and Listeria innocua, its MIC values are ≤0.0625 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1846579-07-4
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Molecular Weight 796.90
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Formula C41H54F2N6O8
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SMILES
[H][C@@]12C[C@H](CN1C([C@@H](NC([C@@]3(CCCCN3C([C@@]4(CCCN4C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/C=C/CCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)[H])=O)C)=O)C
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Synonyms
ADEP26
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025;33(10):1700-1716.e6. [Content Brief]
[2]. Goodreid JD, et al. Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity. J Med Chem. 2016;59(2):624-646. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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