2. Signaling Pathways
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  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3823):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N17043
    3β,5α-Dihydroxystigmastan-6-one
    3β,5α-Dihydroxystigmastan-6-one is a natural steroid.
    3β,5α-Dihydroxystigmastan-6-one
  • HY-N17183
    1,3-Di-O-caffeoyl-4-O-galloyl-β-D-glucopyranose
    1,3-Di-O-caffeoyl-4-O-galloyl-β-D-glucopyranose is a natural phenylacetylene.
    1,3-Di-O-caffeoyl-4-O-galloyl-β-D-glucopyranose
  • HY-N17156
    Methylconiferin
    Methylconiferin is a natural phenylacetylene.
    Methylconiferin
  • HY-176777
    7-Methylol-9-methoxy-10-F-camptothecin
    7-Methylol-9-methoxy-10-F-camptothecin (Compound D6-1) is a derivative of Camptothecin (HY-16560). 7-Methylol-9-methoxy-10-F-camptothecin can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
    7-Methylol-9-methoxy-10-F-camptothecin
  • HY-130229
    (±)5,6-DHET lactone
    5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.
    (±)5,6-DHET lactone
  • HY-N17013
    Dihydrocinchonamine
    Dihydrocinchonamine is a natural alkaloid.
    Dihydrocinchonamine
  • HY-N15554
    Thaigranatumin A
    Thaigranatumin A is a protolimonoid compound found in the seeds of the Thai mangrove (Xylocarpus granatum). Thaigranatumin A is promising for research of neurodegenerative diseases such as Parkinson's diseases.
    Thaigranatumin A
  • HY-184078
    8-F-2-(Me-Pip-Me)-Tryptanthrin
    8-F-2-(Me-Pip-Me)-Tryptanthrin is a tryptanthrin derivative with blood-brain barrier penetration. 8-F-2-(Me-Pip-Me)-Tryptanthrin protects neurons from Aβ-induced apoptosis, inhibits Aβ-induced Tau protein hyperphosphorylation and neuronal synaptic damage, and improves learning and memory abilities in Alzheimer's disease mice. 8-F-2-(Me-Pip-Me)-Tryptanthrin can be used for the research of nervous system diseases, including diseases related to abnormal Tau protein phosphorylation and abnormal PSD-95 function.
    8-F-2-(Me-Pip-Me)-Tryptanthrin
  • HY-N9832
    1,1'-Bislusianthridin
    1,1'-Bislusianthridin is a natural phenolic compound.
    1,1'-Bislusianthridin
  • HY-180327
    NEPP11
    NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion.
    NEPP11
  • HY-N9770
    Juncuenin B
    Juncuenin B is a natural phenolic compound.
    Juncuenin B
  • HY-N17329
    trans-Gnetin H
    trans-Gnetin H is a natural product that can be found in Paeonia lactiflora?Pall..
    trans-Gnetin H
  • HY-178272
    Ecteinascidin-Analog-2
    Ecteinascidin-Analog-2 (example 75) is an Ecteinascidin derivative with antitumor effects.
    Ecteinascidin-Analog-2
  • HY-175106
    8-(4-Azidophenacylthio) NAD+ sodium
    8-(4-Azidophenacylthio) NAD+ sodium is a clickable form of NAD+ (HY-B0445). NAD+ is a coenzyme that transfers hydrogen ions.
    8-(4-Azidophenacylthio) NAD+ sodium
  • HY-N16911
    3'-Deoxyhispolon
    3'-Deoxyhispolon (3'-Deoxyhispolone) is a natural phenolic compound.
    3'-Deoxyhispolon
  • HY-N9827
    Cucurbitacin A 2-O-β-D-glucopyranoside
    Cucurbitacin A 2-O-β-D-glucopyranoside is a natural triterpene.
    Cucurbitacin A 2-O-β-D-glucopyranoside
  • HY-N16693
    Brasilixanthone B
    Brasilixanthone B is a natural xanthone.
    Brasilixanthone B
  • HY-126733
    (6R)-Leucovorin
    (6R)-Leucovorin is a derivative of Folic Acid, a vitamin that plays a crucial role in DNA synthesis, DNA repair, and DNA methylation, and also serves as a cofactor in biological reactions involving folate.
    (6R)-Leucovorin
  • HY-N16833
    Apigenin 6-C-(2-O-feruloyl)glucoside 8-C-glucoside
    Apigenin 6-C-(2-O-feruloyl)glucoside 8-C-glucoside is a natural flavonoid.
    Apigenin 6-C-(2-O-feruloyl)glucoside 8-C-glucoside
  • HY-N17826
    YM-254891
    YM-254891 is a YM-254890 (HY-111557) analogue and Gαq/11 inhibitor. YM-254891 can be isolated from the fermentation broth of Chromobacterium sp. QS3666. YM-254891 inhibits ADP-induced platelet aggregation.
    YM-254891