Endonuclease
Endonuclease
Endonucleases are a class of enzymes that can cleave phosphodiester bonds within nucleic acid molecules. According to the substrates they act on, endonucleases can be classified into DNA endonucleases and RNA endonucleases. According to their structural and functional characteristics, endonucleases can be divided into restriction endonucleases, non-specific endonucleases, and site-specific endonucleases. Endonucleases play an important role in the fields of DNA repair, RNA processing, and genetic engineering. Mutations in the genes encoding endonucleases can lead to genetic diseases, such as xeroderma pigmentosum. Abnormal expression or altered activity of endonucleases may promote tumorigenesis, be involved in the pathological processes of neurodegenerative diseases, and at the same time, endonucleases are also potential targets for the treatment of diseases such as tumors[1][2].
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Endonuclease Produits associés (45)
Produits associés (45)
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Anticorps (1)
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T4 endonuclease VII
0 ImagesCat. No.: HY-E70603T4 endonuclease VII displays broad substrate specificity and can bind and cleave single-base mismatches in a DNA duplex as well as three-way and four-way branched DNA structures.
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Suraxavir marboxil
0 ImagesCat. No.: HY-143744CAS No.: 2364589-86-4Synonyms: GP681; Cap-dependent endonuclease-IN-3Suraxavir marboxil (GP681; Cap-dependent endonuclease-IN-3) is a PA subunit cap-dependent endonuclease inhibitor with antiviral activity. Suraxavir marboxil inhibits PA subunit cap-dependent endonuclease activity and inhibits influenza A and/or influenza B viral replication. Suraxavir marboxil can be used alone or in combination with other anti-influenzal agents for the prevention of influenza A and/or influenza B viral infectious diseases. Suraxavir marboxil can be used for the research of influenza A and/or influenza B viral infectious diseases.
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3'-O-Acetylthymidine
0 ImagesCat. No.: HY-N8525CAS No.: 21090-30-23'-O-Acetylthymidine, a purine nucleoside analog, is an inhibitor of ribonuclease A.
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Cap-dependent endonuclease-IN-29
0 ImagesCat. No.: HY-171729CAS No.: 2408318-14-7Cap-dependent endonuclease-IN-29 is a Cap-dependent endonuclease inhibitor and a stereoselective synthetic intermediate. Cap-dependent endonuclease-IN-29 can be used in research on viral infections.
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PAN endonuclease-IN-3
0 ImagesCat. No.: HY-174431PAN endonuclease-IN-3 is a potent PAN endonuclease inhibitor that against influenza virus polymerase complexes with an IC50 of 17.4 nM. PAN endonuclease-IN-3 demonstrates potent inhibitory activities against PAN endonuclease. PAN endonuclease-IN-3 demonstrates robust antiviral activities against multiple current and different influenza virus strains while showing minimal cytotoxicity in MDCK cells. PAN endonuclease-IN-3 significantly suppresses viral replication in an A/WSN/33 infected mouse model.
