Na+/H+ Exchanger (NHE)
Sodium/hydrogen Exchanger; Sodium-hydrogen Exchanger
Na+/H+ exchanger (sodium/hydrogen exchanger, NHE) family exchanges Na+ for H+ according to their concentration gradients, thus promotes the regulation of the stability of cytoplasmic pH and cell volume.
There are nine isoforms of NHE in humans, some NHEs function primarily on the plasma membrane, and others are present on intracellular organelles. NHE1 is expressed in the plasma membrane of virtually all tissues and plays an important role in cardiac health. NHE2 is expressed in the gastrointestinal (GI) tract and contributes to the maintenance of stomach pH and homeostasis, whereas NHE3 predominates in the GI tract and kidneys. NHE4 and NHE5 are abundant in the stomach and brain, respectively. NHE6-9 are expressed in the intracellular compartments of many organ system membranes, but of these NHE8 is the exception and expressed apically.
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Na+/H+ Exchanger (NHE) Related Products (54)
Related Products (54)
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KR-32568
0 ImagesKR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects.
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EIPA (Standard)
0 ImagesSynonyms: L593754 (Standard); MH 12-43 (Standard); Ethylisopropylamiloride (Standard)EIPA (Standard) is the analytical standard of EIPA. This product is intended for research and analytical applications. EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.
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Zoniporide (Standard)
0 ImagesCat. No.: HY-105064RCAS No.: 241800-98-6Synonyms: CP-597396 (Standard)Zoniporide (Standard) (CP-597396 (Standard)) is the analytical standard of Zoniporide (HY-105064). This product is intended for research and analytical applications. Zoniporide (CP-597396) is a selective Na+/H+ exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide reduces intracellular Na+ and Ca2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury.
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Eniporide hydrochloride (Standard)
0 ImagesCat. No.: HY-106150BRCAS No.: 211813-86-4Synonyms: EMD-96785 hydrochloride (Standard)Eniporide hydrochloride (Standard) is the analytical standard of Eniporide hydrochloride (HY-106150B). This product is intended for research and analytical applications. Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na+/H+ exchange inhibitor.
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Zoniporide hydrochloride hydrate (Standard)
0 ImagesCat. No.: HY-105064DRCAS No.: 863406-85-3Synonyms: CP-597396 hydrochloride hydrate (Standard)Zoniporide hydrochloride hydrate (Standard) (CP-597396 hydrochloride hydrate (Standard)) is the analytical standard of Zoniporide hydrochloride hydrate (HY-105064D). This product is intended for research and analytical applications. Zoniporide hydrochloride hydrate (CP-597396 hydrochloride hydrate) is a selective Na+/H+ exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide hydrochloride hydrate reduces intracellular Na+ and Ca2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide hydrochloride hydrate is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury.
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Cariporide (Standard)
0 ImagesSynonyms: HOE-642 Free Base (Standard)Cariporide (Standard) is the analytical standard of Cariporide. This product is intended for research and analytical applications. Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor.
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BIIB 513
0 ImagesCat. No.: HY-125144CAS No.: 265986-98-9BIIB 513 is an inhibitor of NHE 1 that protects against myocardial ischemia. BIIB 513 inhibits acid load recovery with an IC50 of 27 nmol/L in cells expressing wild-type NHE 1 under acute acid load.
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2-Oxo-zoniporide hydrochloride
0 ImagesCat. No.: HY-W704968CAS No.: 372078-42-72-Oxo-zoniporide hydrochloride is an oral active sodium-hydrogen exchanger type 1 (NHE-1) inhibitor and can be used for study of myocardial ischemic injury.
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Rimeporide hydrochloride
0 ImagesCat. No.: HY-19273ACAS No.: 187870-95-7Synonyms: EMD-87580 hydrochlorideRimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
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Rimeporide-15N3 hydrochloride
0 ImagesCat. No.: HY-W705589Synonyms: EMD-87580-15N3 hydrochlorideRimeporide-15N3 (hydrochloride) (EMD-87580-15N3 (hydrochloride)) is 15N labeled Rimeporide hydrochloride. Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
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EIPA hydrochloride (Standard)
0 ImagesSynonyms: L593754 hydrochloride (Standard); MH 12-43 hydrochloride (Standard); Ethylisopropylamiloride hydrochloride (Standard)EIPA (hydrochloride) (Standard) is the analytical standard of EIPA (hydrochloride). This product is intended for research and analytical applications. EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.
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Eniporide
0 ImagesCat. No.: HY-106150CAS No.: 176644-21-6Synonyms: EMD-96785Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest.
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FR-168888 free base
0 ImagesCat. No.: HY-187612CAS No.: 168620-45-9FR-168888 free base is a Na+/H+ exchanger (NHE) inhibitor (Ki=6.4 nM) with weak inhibitory activity against Na+/Ca2+ exchanger and no cardioprotective effects. FR-168888 free base is widely applicable to studies related to reperfusion-induced ventricular arrhythmias.
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FR183998 free base (Standard)
0 ImagesCat. No.: HY-100302RCAS No.: 239440-20-1FR183998 free base (Standard) is the analytical standard of FR183998 free base (HY-100302). This product is intended for research and analytical applications. FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
