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SWI/SNF Complex Related Products (91)
Related Products (91)
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PROTAC BRM/BRG1 degrader-3
0 ImagesCat. No.: HY-168251CAS No.: 2933125-05-2PROTAC BRM/BRG1 degrader-3 is a BRM/BRG1 PROTAC degrader, exhibiting a DC50 of less than 1 nM for BRM degradation and a DC50 of greater than 1 nM for BRG1 degradation in SW1573 cells. PROTAC BRM/BRG1 degrader-3 shows moderate inhibitory activity against CYP2D6 and hERG. PROTAC BRM/BRG1 degrader-3 inhibits cancer cell proliferation and tumor tissue growth, and exhibits favorable metabolic stability in liver microsomes. PROTAC BRM/BRG1 degrader-3 can be used in non-small cell lung cancer-related research.
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PROTAC BRM/BRG1 degrader-2
0 ImagesCat. No.: HY-168247CAS No.: 2933124-32-2
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PROTAC SMARCA2 degrader-5
0 ImagesCat. No.: HY-159449CAS No.: 2568277-68-7PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 with DC50 of 100-500 nM. (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
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BRM/BRG1 ATP-IN-6
0 ImagesCat. No.: HY-178484CAS No.: 2468049-60-5BRM/BRG1 ATP-IN-6 (Compound 105) is a BRG1/BRM inhibitor. BRM/BRG1 ATP-IN-6 acts on the BAF complex, which is involved in chromatin regulation and gene expression via ATP-dependent chromatin remodeling. BRM/BRG1 ATP-IN-6 demonstrates anti-tumor potential, particularly in cancers associated with BAF complex disorders.
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SMARCA2 Ligand-Linker Conjugate-4
0 ImagesCat. No.: HY-176872CAS No.: 3033001-29-2
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Bromodomain inhibitor-13
0 ImagesCat. No.: HY-122573CAS No.: 1914047-59-8Bromodomain inhibitor-13 (Compound 1) is an analog of PFI-3 (HY-12409). Bromodomain inhibitor-13 is a bromodomain-containing protein (BCP) inhibitor. Bromodomain inhibitor-13 targets SMARCA2, SMARCA4, PB1(5), and second bromodomain of PB1 (PB1(2)) with KD values of 37, 53, 30, and 190 nM, respectively.
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SMARCA2 ligand-6
0 ImagesCat. No.: HY-159542CAS No.: 2408394-89-6
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SMARCA2/4-ligand-2
0 ImagesCat. No.: HY-159545CAS No.: 2568281-88-7SMARCA2/4-ligand-2 is a ligand for target protein for pROTAC.
