2933125-05-2
Chemical Structure
PROTAC BRM/BRG1 degrader-3
- CAS No.: 2933125-05-2
- Formula:C50H63N11O5S
- Molecular Weight:930.17
InChIKey: ABNTYGLZQCYNNM-VONSPCCLSA-N
SMILES: OC(C=CC=C1)=C1C2=CC3=C(N=N2)C(NC(C)C)=NN3C4CCN(CC5CCN(C6=NOC(C(C(N7C[C@H](O)C[C@H]7C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)C(C)C)=C6)CC5)CC4
Biological Activity: PROTAC BRM/BRG1 degrader-3 is a BRM/BRG1 PROTAC degrader, exhibiting a DC50 of less than 1 nM for BRM degradation and a DC50 of greater than 1 nM for BRG1 degradation in SW1573 cells. PROTAC BRM/BRG1 degrader-3 shows moderate inhibitory activity against CYP2D6 and hERG. PROTAC BRM/BRG1 degrader-3 inhibits cancer cell proliferation and tumor tissue growth, and exhibits favorable metabolic stability in liver microsomes. PROTAC BRM/BRG1 degrader-3 can be used in non-small cell lung cancer-related research[1].
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PROTAC BRM/BRG1 degrader-3 | PROTAC BRM/BRG1 degrader-3 is a BRM/BRG1 PROTAC degrader, exhibiting a DC50 of less than 1 nM for BRM degradation and a DC50 of greater than 1 nM for BRG1 degradation in SW1573 cells. PROTAC BRM/BRG1 degrader-3 shows moderate inhibitory activity against CYP2D6 and hERG. PROTAC BRM/BRG1 degrader-3 inhibits cancer cell proliferation and tumor tissue growth, and exhibits favorable metabolic stability in liver microsomes. PROTAC BRM/BRG1 degrader-3 can be used in non-small cell lung cancer-related research. | |||||||||||||||||||||
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Keywords
