1914047-59-8
Chemical Structure
Bromodomain inhibitor-13
- CAS No.: 1914047-59-8
- Formula:C21H22N4O2
- Molecular Weight:362.42
IUPAC Name: (E)-3-((6S,9R)-4-(cyclopropylamino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-10-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one
InChIKey: RQOKOKQQGKYASH-FPBOJHQQSA-N
SMILES: OC1=C(C(/C=C/N2[C@H]3C(N=CN=C4NC5CC5)=C4C[C@@H]2CC3)=O)C=CC=C1
Biological Activity: Bromodomain inhibitor-13 (Compound 1) is an analog of PFI-3 (HY-12409). Bromodomain inhibitor-13 is a bromodomain-containing protein (BCP) inhibitor. Bromodomain inhibitor-13 targets SMARCA2, SMARCA4, PB1(5), and second bromodomain of PB1 (PB1(2)) with KD values of 37, 53, 30, and 190 nM, respectively[1].
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Bromodomain inhibitor-13 | Bromodomain inhibitor-13 (Compound 1) is an analog of PFI-3 (HY-12409). Bromodomain inhibitor-13 is a bromodomain-containing protein (BCP) inhibitor. Bromodomain inhibitor-13 targets SMARCA2, SMARCA4, PB1(5), and second bromodomain of PB1 (PB1(2)) with KD values of 37, 53, 30, and 190 nM, respectively. | |||||||||||||||||||||
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Keywords
