Virus Protease Inhibitor

CHIKV nsP2 protease-IN-3 (Compound 5) is an irreversible covalent inhibitor targeting the nonstructural protein 2 (nsP2) cysteine protease of chikungunya virus (CHIKV) (IC₅₀=0.5 μM). CHIKV nsP2 protease-IN-3 inhibits viral RNA replication. CHIKV nsP2 protease-IN-3 is promising for research of alphaviruses.

SIMR-2418 is an effective inhibitor of the main protease (M^pro) of SARS-CoV-2, with an IC₅₀ value of 20.7 μM. SIMR-2418 can be used for research on SARS-CoV-2 virus infection.

HCV-796 analog is a potent NS5B inhibitor that binds to the palm II site. HCV-796 analog is promising for research of hepatitis C (HCV) infections.

9-Aminominocycline (9-AMN) is the inhibitor for SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro), inhibits its deubiquitination (DUB) activity and protease activity with IC₅₀ of 4.55 µM and 4.15 µM. 9-Aminominocycline inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC₅₀ of 1.04 µM and 2.35 µM.

SARS-CoV-2 Mpro-IN-36 (Compound 6d) is an inhibitor of SARS-CoV-2 M^pro with an IC₅₀ of 110 nM. SARS-CoV-2 Mpro-IN-36 exhibits antiviral activity with an EC₅₀ of 1.6 μM.

(±)-Tuaimenal A ((+)-1) is a secondary metabolite and a derivative of Sesamol (HY-N1417). (±)-Tuaimenal A has potent inhibitory activity against SARS-CoV-2 3CLpro with an IC₅₀ of 33.3  μM. (±)-Tuaimenal A can be used for SARS-CoV-2 infection research.

SARS-CoV-2 Mpro-IN-53 (Compound 7) is a SARS-CoV-2 M^pro inhibitor. SARS-CoV-2 Mpro-IN-53 causes a decrease in M^pro radius of gyration.

AG-1859 is a viral protease inhibitor. AG-1859 can be used in the research of viral infection.

SARS-CoV-2 Mpro-IN-52 (compound 47) is a potent SARS-CoV-2 main protease (MPro) inhibitor (EC₅₀ = 0.0099 µM) with antiviral activity. SARS-CoV-2 Mpro-IN-52 exhibits potent and broad-spectrum activity against MERS, OC43, 229E with EC₅₀s of 0.00961, 0.138, and 0.117 µM. SARS-CoV-2 Mpro-IN-52 can be used for COVID-19 research.

SARS-CoV-2 Mpro-IN-59 is a competitive, nonpeptidic SARS-CoV-2 M_pro inhibitor. SARS-CoV-2 Mpro-IN-59 can be used for the research of covid-19.

Rupintrivir (Standard) is the analytical standard of Rupintrivir (HY-106161). This product is intended for research and analytical applications. Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC₅₀ of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.

SARS-CoV-2 3CLpro-IN-31 (Compound 13c) is a potent SARS-CoV-2 3CL protease (3CLpro) inhibitor of with an IC₅₀ value of 37.33 nM. SARS-CoV-2 3CLpro-IN-31 blocks viral polyprotein cleavage and inhibits SARS-CoV-2 replication. SARS-CoV-2 3CLpro-IN-31 is promising for research of SARS-CoV-2 infection.

4E2RCat (Standard) is the analytical standard of 4E2RCat (HY-100733). This product is intended for research and analytical applications. 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.

Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (M^pro), which can be used in the research of anti-novel coronavirus drugs.

ZHAWOC25153 (Compound 17o) is a SARS-CoV-2 papain-like cysteine protease (PLpro) inhibitor, with an IC₅₀ of 7 μM. ZHAWOC25153 exhibits antiviral activity and can be used in research within the field of anti-infection.