149934-19-0
Chemical Structure
9-Aminominocycline
Synonym(s): 9-AMN
- CAS No.: 149934-19-0
- Formula:C23H28N4O7
- Molecular Weight:472.49
InChIKey: LRNDAPDRSWLZSE-IRDJJEOVSA-N
SMILES: O[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C(N)=CC(N(C)C)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C
Biological Activity: 9-Aminominocycline (9-AMN) is the inhibitor for SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro), inhibits its deubiquitination (DUB) activity and protease activity with IC50 of 4.55 µM and 4.15 µM. 9-Aminominocycline inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC50 of 1.04 µM and 2.35 µM[1].
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9-Aminominocycline | 9-Aminominocycline (9-AMN) is the inhibitor for SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro), inhibits its deubiquitination (DUB) activity and protease activity with IC50 of 4.55 µM and 4.15 µM. 9-Aminominocycline inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC50 of 1.04 µM and 2.35 µM. | |||||||||||||||||||||
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