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Cat. No.: HY-106247

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AG-1859

AG-1859 is a viral protease inhibitor. AG-1859 can be used in the research of viral infection.

For research use only. We do not sell to patients.

CAS No.: 478410-84-3
Formula: C₂₇H₃₃N₃O₅S
Molecular Weight:511.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AG-1859 Chemical Structure

CAS No.: 478410-84-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

AG-1859 is a viral protease inhibitor. AG-1859 can be used in the research of viral infection^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	EC₅₀	0.123 μM Compound: 7k, KNI-1317	Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 19954246]
MT4	EC₅₀	0.141 μM Compound: 7k, KNI-1317	Antiviral activity against HIV1 pNL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against HIV1 pNL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 19954246]
MT4	EC₅₀	0.173 μM Compound: 7k, KNI-1317	Antiviral activity against indinavir-resistant HIV1 harboring L10R/M46I/L63P/V82T/I84V mutant protease infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against indinavir-resistant HIV1 harboring L10R/M46I/L63P/V82T/I84V mutant protease infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 19954246]

Chemical Information

CAS No. 478410-84-3
Molecular Weight 511.63
Formula C₂₇H₃₃N₃O₅S
SMILES

C=CCNC([C@H]1N(CSC1(C)C)C([C@@H](O)[C@@H](NC(C2=C(C(O)=CC=C2)C)=O)CC3=CC=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Howard Gendelman, et al. Lipid nanoparticles and methods of use thereof. WO2025030072A1. WIPO (PCT). 2024-08-02.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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