1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. (S)-Dolaphenine hydrochloride

(S)-Dolaphenine hydrochloride is a component of Dolastatin 10 (HY-15580). Dolastatin 10, an antineoplastic agent, inhibits tubulin polymerization.

For research use only. We do not sell to patients.

(S)-Dolaphenine hydrochloride Chemical Structure

(S)-Dolaphenine hydrochloride Chemical Structure

CAS No. : 135383-60-7

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Solid + Solvent
10 mM * 1 mL in DMSO
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Description

(S)-Dolaphenine hydrochloride is a component of Dolastatin 10 (HY-15580). Dolastatin 10, an antineoplastic agent, inhibits tubulin polymerization[1].

Molecular Weight

240.75

Formula

C11H13ClN2S

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N[C@H](C1=NC=CS1)CC2=CC=CC=C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (207.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (207.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1537 mL 20.7684 mL 41.5369 mL
5 mM 0.8307 mL 4.1537 mL 8.3074 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.1537 mL 20.7684 mL 41.5369 mL 103.8422 mL
5 mM 0.8307 mL 4.1537 mL 8.3074 mL 20.7684 mL
10 mM 0.4154 mL 2.0768 mL 4.1537 mL 10.3842 mL
15 mM 0.2769 mL 1.3846 mL 2.7691 mL 6.9228 mL
20 mM 0.2077 mL 1.0384 mL 2.0768 mL 5.1921 mL
25 mM 0.1661 mL 0.8307 mL 1.6615 mL 4.1537 mL
30 mM 0.1385 mL 0.6923 mL 1.3846 mL 3.4614 mL
40 mM 0.1038 mL 0.5192 mL 1.0384 mL 2.5961 mL
50 mM 0.0831 mL 0.4154 mL 0.8307 mL 2.0768 mL
60 mM 0.0692 mL 0.3461 mL 0.6923 mL 1.7307 mL
80 mM 0.0519 mL 0.2596 mL 0.5192 mL 1.2980 mL
100 mM 0.0415 mL 0.2077 mL 0.4154 mL 1.0384 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S)-Dolaphenine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(S)-Dolaphenine hydrochloride
Cat. No.:
HY-78828A
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