(S)-Dolaphenine hydrochloride

Name: (S)-Dolaphenine hydrochloride
Brand: MedChemExpress
SKU: HY-78828A
Rating: 4.5 (1 reviews)

製品番号: HY-78828A 純度: 98.54%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

(S)-Dolaphenine hydrochloride is a component of Dolastatin 10 (HY-15580). Dolastatin 10, an antineoplastic agent, inhibits tubulin polymerization.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

(S)-Dolaphenine hydrochloride 構造式

CAS 番号 : 135383-60-7

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 176	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 176	在庫あり	Estimated Time of Arrival: December 31
Solid
100 mg	$160	在庫あり	Estimated Time of Arrival: December 31
500 mg	$400	在庫あり	Estimated Time of Arrival: December 31
1 g	$660	在庫あり	Estimated Time of Arrival: December 31
5 g		お問い合わせ
10 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

(S)-Dolaphenine hydrochloride is a component of Dolastatin 10 (HY-15580). Dolastatin 10, an antineoplastic agent, inhibits tubulin polymerization^[1].

分子量

240.75

分子式

C₁₁H₁₃ClN₂S

CAS 番号

135383-60-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

N[C@H](C1=NC=CS1)CC2=CC=CC=C2.Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : ≥ 50 mg/mL (207.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (207.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1537 mL	20.7684 mL	41.5369 mL
5 mM	0.8307 mL	4.1537 mL	8.3074 mL
10 mM	0.4154 mL	2.0768 mL	4.1537 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 98.54%

Select Batch:

データシート (273 KB) SDS (393 KB)

COA (255 KB) HNMR (263 KB) LCMS (103 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Zhou W , et al. A practical approach to asymmetric synthesis of dolastatin 10. Org Biomol Chem. 2017;15(29):6119-6131. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.1537 mL	20.7684 mL	41.5369 mL	103.8422 mL
	5 mM	0.8307 mL	4.1537 mL	8.3074 mL	20.7684 mL
	10 mM	0.4154 mL	2.0768 mL	4.1537 mL	10.3842 mL
	15 mM	0.2769 mL	1.3846 mL	2.7691 mL	6.9228 mL
	20 mM	0.2077 mL	1.0384 mL	2.0768 mL	5.1921 mL
	25 mM	0.1661 mL	0.8307 mL	1.6615 mL	4.1537 mL
	30 mM	0.1385 mL	0.6923 mL	1.3846 mL	3.4614 mL
	40 mM	0.1038 mL	0.5192 mL	1.0384 mL	2.5961 mL
	50 mM	0.0831 mL	0.4154 mL	0.8307 mL	2.0768 mL
	60 mM	0.0692 mL	0.3461 mL	0.6923 mL	1.7307 mL
	80 mM	0.0519 mL	0.2596 mL	0.5192 mL	1.2980 mL
	100 mM	0.0415 mL	0.2077 mL	0.4154 mL	1.0384 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.