2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. AGI-12026

AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

AGI-12026

AGI-12026 Chemical Structure

CAS No. : 1446501-77-4

Size Prix Stock Quantité
1 mg Obtenir un devis 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks
5 mg Obtenir un devis 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks
10 mg Obtenir un devis 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks
25 mg Obtenir un devis 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks
50 mg Obtenir un devis 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks
100 mg Obtenir un devis 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks
200 mg   Obtenir un devis  
500 mg   Obtenir un devis  
Synthetic products have potential research and development risk.

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Avis client

Based on 1 Customer Validation

AGI-12026 Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform Isocitrate Dehydrogenase (IDH):

Voir toutes les isoformes
IDH1 IDH2

  • Activité biologique

  • Pureté et documentation

  • Références

  • Avis client

Description

AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma[1].

Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
0.019 μM
Compound: AGI-12026
Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 16 hrs followed by substrate addition and measured after 1 hr by Diaphorase/Resazurin dye based fluorescence assay
Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 16 hrs followed by substrate addition and measured after 1 hr by Diaphorase/Resazurin dye based fluorescence assay
[PMID: 32071674]
Masse moléculaire

443.35

Formule

C18H15F6N7
CAS No.
SMILES

FC(F)(F)C1=CC=CC(C2=NC(NC(C)C)=NC(NC3=CC(C(F)(F)F)=NC=C3)=N2)=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AGI-12026 Related Classifications

  • Calculateur de molarité

  • Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGI-120261446501-77-4AGI-026AGI12026AGI 12026AGI026AGI 026Isocitrate Dehydrogenase (IDH)brain-penetrantIDH1IDH2IDH1-R132H homodimerallosteric modulatorgliomaInhibitorinhibitorinhibit

Vos produits récemment consultés:

Demande en ligne

Your information is safe with us. * Required Fields.

Nom du produit

  

Requested Quantity *

Nom du demandeur *

 

Civilité

Adresse e-mail *

 

Numéro de téléphone *

Department

 

Nom de l'organisation *

City

État

Country or Region *

      

Remarques

Bulk Inquiry

Inquiry Information

Nom du produit:
AGI-12026
Cat. No.:
HY-121736
Quantité:
MCE Japan Authorized Agent:

Avis client

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nom du produit

  

Lot #

Nom du demandeur *

 

Adresse e-mail *

Numéro de téléphone

 

Department *

Nom de l'organisation *

 

Country or Region *

Remarques

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.