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United States

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製品番号: HY-187377

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α-Glucosidase-IN-121

α-Glucosidase-IN-121 is a yeast α-glucosidase inhibitor with an IC₅₀ of 3.8 μM and a K_i of 12.9 μM. α-Glucosidase-IN-121 binds to the active site of the enzyme, competes with substrate binding, and forms stable interactions with Phe137, Ser308, Pro309, Arg312 and Glu350 via hydrogen bonding, π-π stacking and hydrophobic interactions. α-Glucosidase-IN-121 can be used in the research of diabetes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₃H₁₇N₃O₉S
分子量:511.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Glucosidase-IN-121 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

α‑glucosidase

12.9 μM (Ki)

α‑glucosidase

3.8 μM (IC₅₀)

体外実験

α-Glucosidase-IN-121 (compound 8) (10 μM; 20 min) can strongly inhibit α-glucosidase in Saccharomyces cerevisiae, with an IC₅₀ of 3.8 μM; it can also be used as a competitive inhibitor of α-glucosidase in Saccharomyces cerevisiae, with a K_i value of 12.9 μM^[1].
α-Glucosidase-IN-121 binds to Saccharomyces cerevisiae α-glucosidase with a binding energy of -11.3 kcal/mol via hydrogen bonds, π−π stacking, and a salt bridge with key active site residues^[1].
α-Glucosidase-IN-121 forms a stable complex with Saccharomyces cerevisiae α-glucosidase over 100 ns of molecular dynamics simulation, maintaining consistent hydrogen bonding and reducing enzyme domain fluctuations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 511.46
分子式 C₂₃H₁₇N₃O₉S
SMILES

O=[N+]([O-])C(C=C1)=CC=C1S(NNC(COC2=CC(O)=C(C(C=C(C3=CC=CC=C3)O4)=O)C4=C2)=O)(=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ayandokun TF, et al. Design, Synthesis, In Vitro, and In Silico Enzymatic Evaluations of New Chrysin Sulfonohydrazide Derivatives as Potent α‑Glucosidase Inhibitors. ACS omega. 2026 Jul 28;11(29):43921-43930. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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