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Cat. No.: HY-187377

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α-Glucosidase-IN-121

α-Glucosidase-IN-121 is a yeast α-glucosidase inhibitor with an IC₅₀ of 3.8 μM and a K_i of 12.9 μM. α-Glucosidase-IN-121 binds to the active site of the enzyme, competes with substrate binding, and forms stable interactions with Phe137, Ser308, Pro309, Arg312 and Glu350 via hydrogen bonding, π-π stacking and hydrophobic interactions. α-Glucosidase-IN-121 can be used in the research of diabetes.

For research use only. We do not sell to patients.

Formula: C₂₃H₁₇N₃O₉S
Molecular Weight:511.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Glucosidase-IN-121 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

α‑glucosidase

12.9 μM (Ki)

α‑glucosidase

3.8 μM (IC₅₀)

In Vitro

α-Glucosidase-IN-121 (compound 8) (10 μM; 20 min) can strongly inhibit α-glucosidase in Saccharomyces cerevisiae, with an IC₅₀ of 3.8 μM; it can also be used as a competitive inhibitor of α-glucosidase in Saccharomyces cerevisiae, with a K_i value of 12.9 μM^[1].
α-Glucosidase-IN-121 binds to Saccharomyces cerevisiae α-glucosidase with a binding energy of -11.3 kcal/mol via hydrogen bonds, π−π stacking, and a salt bridge with key active site residues^[1].
α-Glucosidase-IN-121 forms a stable complex with Saccharomyces cerevisiae α-glucosidase over 100 ns of molecular dynamics simulation, maintaining consistent hydrogen bonding and reducing enzyme domain fluctuations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 511.46
Formula C₂₃H₁₇N₃O₉S
SMILES

O=[N+]([O-])C(C=C1)=CC=C1S(NNC(COC2=CC(O)=C(C(C=C(C3=CC=CC=C3)O4)=O)C4=C2)=O)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ayandokun TF, et al. Design, Synthesis, In Vitro, and In Silico Enzymatic Evaluations of New Chrysin Sulfonohydrazide Derivatives as Potent α‑Glucosidase Inhibitors. ACS omega. 2026 Jul 28;11(29):43921-43930.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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