Alterporriol C
Alterporriol C is an alternariol-type anthraquinone dimer isolated from the fungus Alternaria sp. ZJ-2008003, with antibacterial and antiviral activities. Alterporriol C inhibits the growth of Escherichia coli and Vibrio parahaemolyticus (MIC = 2.5 μM), and suppresses the replication of porcine reproductive and respiratory syndrome virus (PRRSV) (IC50 = 39 μM). Alterporriol C can be used in studies related to bacterial and viral infections.
For research use only. We do not sell to patients.
- CAS No.: 118074-08-1
- Formula: C32H26O13
- Molecular Weight:618.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Endogenous Metabolite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 22, atropisomer-1
|
Cytotoxic activity against human A549 cells by MTT assay
Cytotoxic activity against human A549 cells by MTT assay
|
[PMID: 25136754] |
| B16-F10 | IC50 |
>10 μM
Compound: 22, atropisomer-1
|
Cytotoxic activity against mouse B16F10 cells by MTT assay
Cytotoxic activity against mouse B16F10 cells by MTT assay
|
[PMID: 25136754] |
| HCT-116 | IC50 |
24 μM
Compound: 17
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Cytotoxicity against human HCT116 cells after 6 days by MTT assay
Cytotoxicity against human HCT116 cells after 6 days by MTT assay
|
[PMID: 22276679] |
| Hep 3B2 | IC50 |
51 μM
Compound: 17
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Cytotoxicity against human Hep3B cells after 6 days by MTT assay
Cytotoxicity against human Hep3B cells after 6 days by MTT assay
|
[PMID: 22276679] |
| HepG2 | IC50 |
53 μM
Compound: 17
|
Cytotoxicity against human HepG2 cells after 6 days by MTT assay
Cytotoxicity against human HepG2 cells after 6 days by MTT assay
|
[PMID: 22276679] |
| NCI/ADR-RES | IC50 |
98 μM
Compound: 17
|
Cytotoxicity against human MCF7/ADR cells after 6 days by MTT assay
Cytotoxicity against human MCF7/ADR cells after 6 days by MTT assay
|
[PMID: 22276679] |
| PC-3 | IC50 |
27 μM
Compound: 17
|
Cytotoxicity against human PC3 cells after 6 days by MTT assay
Cytotoxicity against human PC3 cells after 6 days by MTT assay
|
[PMID: 22276679] |
Alterporriol C (compound 26) shows no cytotoxic activity against HCT-116, MCF-7/ADR, PC-3, HepG2, and Hep3B cell lines, with IC50 > 20 μM[1].
Alterporriol C potently inhibits the growth of E. coli and V. parahemolyticus with an MIC of 2.5 μM for each, and inhibits PRRSV replication with an IC50 of 39 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 118074-08-1
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Molecular Weight 618.54
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Formula C32H26O13
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SMILES
O=C1C2=CC(OC)=CC(O)=C2C(C3=C1C=C(C)C(O)=C3C4=C(C(C(C5=C6[C@H]([C@@](C)([C@@H]([C@H]5O)O)O)O)=O)=C(C=C4OC)C6=O)O)=O
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Structure Classification
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Initial Source
Stemphylium sp. 33231
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)