2. PROTAC
  3. PROTAC Linkers
  4. Amino-PEG7-t-butyl ester

Amino-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG7-t-butyl ester Chemical Structure

Amino-PEG7-t-butyl ester Chemical Structure

CAS No. : 2428400-07-9

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500 mg USD 186 In-stock
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Based on 1 publication(s) in Google Scholar

Amino-PEG7-t-butyl ester Related Antibodies

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Description

Amino-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amino-PEG7-t-butyl ester Related Antibodies
Molecular Weight

453.57

Formula

C21H43NO9
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCOCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (220.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2047 mL 11.0237 mL 22.0473 mL
5 mM 0.4409 mL 2.2047 mL 4.4095 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2047 mL 11.0237 mL 22.0473 mL 55.1183 mL
5 mM 0.4409 mL 2.2047 mL 4.4095 mL 11.0237 mL
10 mM 0.2205 mL 1.1024 mL 2.2047 mL 5.5118 mL
15 mM 0.1470 mL 0.7349 mL 1.4698 mL 3.6746 mL
20 mM 0.1102 mL 0.5512 mL 1.1024 mL 2.7559 mL
25 mM 0.0882 mL 0.4409 mL 0.8819 mL 2.2047 mL
30 mM 0.0735 mL 0.3675 mL 0.7349 mL 1.8373 mL
40 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3780 mL
50 mM 0.0441 mL 0.2205 mL 0.4409 mL 1.1024 mL
60 mM 0.0367 mL 0.1837 mL 0.3675 mL 0.9186 mL
80 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6890 mL
100 mM 0.0220 mL 0.1102 mL 0.2205 mL 0.5512 mL
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Amino-PEG7-t-butyl ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amino-PEG7-t-butyl ester2428400-07-9PROTAC LinkersInhibitorinhibitorinhibit

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