1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Antazoline

Antazoline (Synonyms: Phenazoline)

Cat. No.: HY-B1067A
Handling Instructions

Antazoline (Phenazoline) is an H1 receptor
antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect.

For research use only. We do not sell to patients.

Antazoline Chemical Structure

Antazoline Chemical Structure

CAS No. : 91-75-8

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Description

Antazoline (Phenazoline) is an H1 receptor
antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect[1][2][3].

IC50 & Target

H1 receptor

In Vitro

Antazoline (Phenazoline) shows good inhibitory effect on HBV DNA in the supernatant of HepAD38 and Huh7 cells with the value of EC50 is 2.910 μmol/L and 2.349 μmol/L, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: HepAD38 cells
Concentration: 10μmol/L
Incubation Time: 5 days
Result: Exhibited no significant cytotoxicity at a concentration of 10μmol/L and had a dose-dependent inhibition of HBV DNA in the supernatant.

RT-PCR[2]

Cell Line: Huh7 cells
Concentration: 30 μmol/L, 10 μmol/L, 3.33 μmol/L, 1.1 μmol/L, 0.370 μmol/L, and 0.123 μmol/L
Incubation Time: 4 days
Result: Had a significant inhibitory effect on HBV DNA in supernatants in a dose-dependent manner.
In Vivo

Antazoline (IP; 0.01 ml/g; 30min) as H1 receptor antagonists diminishes the anticonvulsant activity of carbamazepine and diphenylhydantoin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice[3]
Dosage: 0.01 mL/g
Administration: Antazoline (IP; 0.01 ml/g; 30min)
Result: Showed some proconvulsive activity.
Molecular Weight

265.35

Formula

C17H19N3

CAS No.
SMILES

C1(CN(C2=CC=CC=C2)CC3=CC=CC=C3)=NCCN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antazoline
Cat. No.:
HY-B1067A
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