2. Immunology/Inflammation Apoptosis
  3. Transmembrane Glycoprotein TNF Receptor
  4. Anti-Mouse CD40 Antibody (FGK4.5/FGK45)

Anti-Mouse CD40 Antibody (FGK4.5/FGK45) 

製品番号: HY-P990680 純度: 98.35%
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Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is an agonistic rat-derived IgG2a monoclonal antibody targeting mouse CD40. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) enhances T cells responses, dendritic cells maturation and NK cells activation. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) can be used for the researches of cancer, infection, inflammation and immunology, such as CT26 tumor, vesicular stomatitis virus (VSV) infection and transplantation.

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Anti-Mouse CD40 Antibody (FGK4.5/FGK45)

Anti-Mouse CD40 Antibody (FGK4.5/FGK45) 構造式

容量 価格（税別） 在庫状況 数量
>無料サンプル (100 μg)   今すぐ申し込む  
1 mg $220 在庫あり
5 mg $650 在庫あり
10 mg $1050 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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製品説明

Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is an agonistic rat-derived IgG2a monoclonal antibody targeting mouse CD40. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) enhances T cells responses, dendritic cells maturation and NK cells activation. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) can be used for the researches of cancer, infection, inflammation and immunology, such as CT26 tumor, vesicular stomatitis virus (VSV) infection and transplantation[1][2][3].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
体内実験

Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (200 μg at day 0 and 100 μg at day 3, 7, 10, i.p.) induces the expression of IL-15Rα in C57BL/6 mice[1].
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (200 μg at day 0 and 100 μg at day 3, 7, 10, i.p.) inhibits tumor growth and prolongs survival in CT26/MC38 tumor mice models[1].
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (100 μg, i.p., 1 day after infection) enhances CD8+ T cell response and dendritic cell maturation in vesicular stomatitis virus (VSV)-infected mice models[2].
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (100 μg, i.v., at day 0 and 1) promotes the accumulation of immunogenic macrophages and abrogates the induction of tolerance in vascularized heart transplanted mice models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26/MC38 tumor mice models[1]
Dosage: 200 μg at day 0 and 100 μg at day 3, 7, 10
Administration: Intraperitoneally injection, companied with anti-IL-15
Result: Prolonged survival of mice.
Suppressed tumor growth.
Showed increased lysis activity of NK cells at days 2 and 5.
Animal Model: Vesicular stomatitis virus (VSV)- infected mice models[2]
Dosage: 100 μg
Administration: Intraperitoneally injection, 1 day after infection
Result: Resulted in a nearly three-fold larger memory CD8+ T cell population.
Increased proportion of IFNγ+ TNFα+dual producing CD8+ T cells.
Animal Model: Vascularized heart transplanted mice models[3]
Dosage: 100 μg
Administration: Intravenously injection, at day 0 and 1
Result: Increased immunogenic macrophages and IFN-γ expression.
Gene ID

21939  [NCBI]

Accession
Application

in vivo CD40 activation; in vitro B cell stimulation/activation
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD40 Antibody (FGK4.5/FGK45)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Anti-Mouse CD40 Antibody (FGK4.5/FGK45) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD40 Antibody (FGK4.5/FGK45)Transmembrane GlycoproteinTNF ReceptorTumor Necrosis Factor ReceptorTNFRCD40T cellsDendritic cellsNK cellsCT26MC38Vesicular stomatitis virusMacrophagesInhibitorinhibitorinhibit

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製品名:
Anti-Mouse CD40 Antibody (FGK4.5/FGK45)
製品番号:
HY-P990680
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