Anti-Mouse CD40 Antibody (FGK4.5/FGK45)
Based on 1 publication(s) in Google Scholar
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is an agonistic rat-derived IgG2a monoclonal antibody targeting mouse CD40. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) enhances T cells responses, dendritic cells maturation and NK cells activation. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) can be used for the researches of cancer, infection, inflammation and immunology, such as CT26 tumor, vesicular stomatitis virus (VSV) infection and transplantation.
For research use only. We do not sell to patients.
- Purity: 98.35%
- Molecular Weight:150 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-Mouse CD40 Antibody (FGK4.5/FGK45)
More
Biological Activity
Description
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
In Vivo
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (200 μg at day 0 and 100 μg at day 3, 7, 10, i.p.) inhibits tumor growth and prolongs survival in CT26/MC38 tumor mice models[1].
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (100 μg, i.p., 1 day after infection) enhances CD8+ T cell response and dendritic cell maturation in vesicular stomatitis virus (VSV)-infected mice models[2].
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (100 μg, i.v., at day 0 and 1) promotes the accumulation of immunogenic macrophages and abrogates the induction of tolerance in vascularized heart transplanted mice models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:CT26/MC38 tumor mice models[1]
-
Dosage:200 μg at day 0 and 100 μg at day 3, 7, 10
-
Administration:Intraperitoneally injection, companied with anti-IL-15
-
Result:Prolonged survival of mice.
Suppressed tumor growth.
Showed increased lysis activity of NK cells at days 2 and 5.
-
Animal Model:Vesicular stomatitis virus (VSV)- infected mice models[2]
-
Dosage:100 μg
-
Administration:Intraperitoneally injection, 1 day after infection
-
Result:Resulted in a nearly three-fold larger memory CD8+ T cell population.
Increased proportion of IFNγ+ TNFα+dual producing CD8+ T cells.
-
Animal Model:Vascularized heart transplanted mice models[3]
-
Dosage:100 μg
-
Administration:Intravenously injection, at day 0 and 1
-
Result:Increased immunogenic macrophages and IFN-γ expression.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Product Image
Application
in vivo CD40 activation; in vitro B cell stimulation/activation
Chemical Information
-
Appearance Liquid
-
Molecular Weight 150 kDa
-
Color Colorless to light yellow
-
SMILES
[Anti-Mouse CD40 Antibody (FGK4.5/FGK45)]
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
Purity & Documentation
-
Data Sheet (262 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1]. Zhang M, et al. Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7513-8. [Content Brief]
[2]. Zickovich JM, et al. Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection. PLoS One. 2014 Aug 28;9(8):e106060. [Content Brief]
[3]. Conde P, et al. DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance. Immunity. 2015 Jun 16;42(6):1143-58. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) Related Classifications
HY-P990680 Related Classifications
Powered by Bioz