2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD8α Antibody (YTS 105.18)

Anti-Mouse CD8α Antibody (YTS 105.18) 

Cat. No.: HY-P992063
Technical Support

Anti-Mouse CD8α Antibody (YTS 105.18) is a non-depleting rat IgG2a monoclonal antibody. Anti-Mouse CD8α Antibody (YTS 105.18) binds to CD8α (epitope c) on mouse CD8+ T cells; when used in combination with a non-depleting anti-CD4 antibody, it does not deplete CD8+ T cells but instead promotes the induction of peripheral tolerance in this cell subset. Anti-Mouse CD8α Antibody (YTS 105.18) can be used in studies of graft rejection.

For research use only. We do not sell to patients.

Anti-Mouse CD8α Antibody (YTS 105.18)

Anti-Mouse CD8α Antibody (YTS 105.18) Chemical Structure

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Description

Anti-Mouse CD8α Antibody (YTS 105.18) is a non-depleting rat IgG2a monoclonal antibody. Anti-Mouse CD8α Antibody (YTS 105.18) binds to CD8α (epitope c) on mouse CD8+ T cells; when used in combination with a non-depleting anti-CD4 antibody, it does not deplete CD8+ T cells but instead promotes the induction of peripheral tolerance in this cell subset. Anti-Mouse CD8α Antibody (YTS 105.18) can be used in studies of graft rejection[1].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
In Vitro

YTS 105.18 (Anti-Mouse CD8α Antibody) binds to Ly-2-transfected mouse L cells and is a rat IgG2a isotype antibody[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD8α Antibody (YTS 105.18) Related Antibodies
In Vivo

Anti-Mouse CD8α Antibody (YTS 105.18) (7 mg total per mouse; every other day; 2 weeks) co-administered with a non-depleting anti-CD4 antibody induces permanent, antigen-specific transplantation tolerance to minor antigen-mismatched B10.BR skin allografts in CBA/Ca mice, with sustained survival of primary and secondary donor grafts beyond 200 days while preserving immunocompetence to reject third-party grafts[1].
Anti-Mouse CD8α Antibody (YTS 105.18) (7 mg total per mouse; 1-3 weeks) co-administered with a non-depleting anti-CD4 antibody enables chimerism induction and permanent transplantation tolerance to minor antigen-mismatched B10.BR bone marrow and skin allografts in CBA/Ca mice[1].
Anti-Mouse CD8α Antibody (YTS 105.18) (7 mg total per mouse; three times per week; 3 weeks) co-administered with a non-depleting anti-CD4 antibody modulates CD4 antigen expression in normal CBA/Ca mice without causing significant depletion of CD4+ or CD8+ T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CBA/Ca mice (age- and sex-matched)[1]
Dosage: 7 mg total per mouse
Administration: every other day; 2 weeks
Result: Enabled all treated mice to accept initial B10.BR skin graft for >90 days.
Sustained survival of initial and second B10.BR grafts for >200 days.
Induced immediate rejection of third-party BALB/c skin graft.
Caused no significant depletion of CD4+ T cells at end of treatment.
Resulted in undetectable residual antibody after day 42.
Animal Model: CBA/Ca mice (age- and sex-matched)[1]
Dosage: 7 mg total per mouse
Administration: three times per week; 3 weeks
Result: Produced minimal reduction in total T cell numbers.
Caused significant modulation of CD4 antigen expression.
Resulted in no depletion of CD8+ cells, as evidenced by total rat IgG2a-coated cells exceeding CD4+ cells alone and a significant Thy-1+CD4-CD8- population in treated mice.
Gene ID

12525  [NCBI]

Accession
Target

CD8α
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[Anti-Mouse CD8α Antibody (YTS 105.18)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD8α Antibody (YTS 105.18) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD8α Antibody (YTS 105.18)Transmembrane Glycoproteinallograft rejectionskin allograftsperipheral toleranceminor transplantation antigensmurine CD8+ T cellsbone marrow allograftsCD8αCD4+ T cellseuthymic miceadult thymectomized miceInhibitorinhibitorinhibit

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