Anti-Mouse TCRβ Antibody (HB218)
Anti-Mouse TCRβ Antibody (HB218) is an anti-mouse TCRβ IgG2b monoclonal antibody. Anti-Mouse TCRβ Antibody (HB218) can deplete TCRβ+ T cells. Anti-Mouse TCRβ Antibody (HB218) can be used for research on inflammation conditions and cancer such as spontaneous dermatitis and squamous cell carcinoma (SCC).
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity
Mouse
In Vivo
Anti-Mouse TCRβ Antibody (HB218) (250 µg, i.p., on day 0, 3 and 12 for preventive experiment, on day 9 and 16 for extinction experiment) can exhaust all T cells in HPV38E6E7-FVB mice bearing SCC tumors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD18-/- PL/J N6 mice (5 weeks)[1]
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Dosage:100 µg, combined with CD4 mAb and CD8 mAb
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Administration:Intraperitoneal injection (i.p.), once daily for 4 days, then once every 4 days for 1 month
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Result:Significantly delayed disease occurrence to 23.9 weeks (control group 10.2 weeks).
Reduced the number of TCRβ+ T cells.
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Animal Model:1×106 HPV38 SCC cells injected HPV38E6E7-FVB mice[2]
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Dosage:250 µg
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Administration:Intraperitoneal injection (i.p.), on day 0, 3 and 12 for preventive experiment, on day 9 and 16 for extinction experiment
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Result:Caused rapid tumor growth.
Shortened the survival period.
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo T cell depletion
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Mouse TCRβ Antibody (HB218)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Barlow SC, et al. Development of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytes. Int Immunol. 2004 Feb;16(2):345-51. [Content Brief]
[2]. Zeng Z, et al. IFN-γ Critically Enables the Intratumoural Infiltration of CXCR3+ CD8+ T Cells to Drive Squamous Cell Carcinoma Regression. Cancers (Basel). 2021 Apr 28;13(9):2131. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse TCRβ Antibody (HB218) Related Classifications
HY-P990159 Related Classifications
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