AFAP1L2 Antibody (YA4369)
(Synonyms: XB130; KIAA1914; CTB-1144G6.4)AFAP1L2 Antibody (YA4369) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AFAP1L2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
AFAP1L2 Antibody (YA4369) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AFAP1L2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 91 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 91.3 kDa
Purified recombinant fragment of human AFAP1L2 (AA: 674-818) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
AFAP1L2 is a Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor
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Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton; Nucleus
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Expression
Tissue_specificity:general expression
Induction:Up-regulated at protein level by cell density. However, at the mRNA level remains the same regardless of the status of cell density -
Subunit
Interacts with FLT4; the interaction is enhanced by stimulation with VEGFC. Interacts (via PPxY motifs) with YAP1 (via WW domains); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional co-activator activity
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SwissProt ID
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Synonyms
XB130; KIAA1914; CTB-1144G6.4
Documentation
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