AFAP1L2 - actin filament associated protein 1 like 2 Gene

Also Known as XB130; KIAA1914; CTB-1144G6.4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84632

About AFAP1L2

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:114,280,725-114,405,175 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in thyroid (RPKM 34.2), spleen (RPKM 23.9) and 15 other tissues.

Summary

Enables SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

AFAP1L2 Products (20)

mRNA Protein Name
NM_001001936.3 NP_001001936.1 actin filament-associated protein 1-like 2 isoform 1
NM_001287824.2 NP_001274753.1 actin filament-associated protein 1-like 2 isoform 3
NM_001351064.2 NP_001337993.1 actin filament-associated protein 1-like 2 isoform 4
NM_001351065.2 NP_001337994.1 actin filament-associated protein 1-like 2 isoform 5
NM_001351066.2 NP_001337995.1 actin filament-associated protein 1-like 2 isoform 6
NM_001351067.2 NP_001337996.1 actin filament-associated protein 1-like 2 isoform 7
NM_001351068.2 NP_001337997.1 actin filament-associated protein 1-like 2 isoform 8
NM_001351069.2 NP_001337998.1 actin filament-associated protein 1-like 2 isoform 9
NM_001351070.2 NP_001337999.1 actin filament-associated protein 1-like 2 isoform 10
NM_001351071.2 NP_001338000.1 actin filament-associated protein 1-like 2 isoform 11
NM_001351072.2 NP_001338001.1 actin filament-associated protein 1-like 2 isoform 12
NM_001351073.2 NP_001338002.1 actin filament-associated protein 1-like 2 isoform 13
NM_001351074.2 NP_001338003.1 actin filament-associated protein 1-like 2 isoform 14
NM_001351075.2 NP_001338004.1 actin filament-associated protein 1-like 2 isoform 15
NM_001351076.2 NP_001338005.1 actin filament-associated protein 1-like 2 isoform 16
NM_001351077.2 NP_001338006.1 actin filament-associated protein 1-like 2 isoform 17
NM_001351078.2 NP_001338007.1 actin filament-associated protein 1-like 2 isoform 18
NM_001351079.2 NP_001338008.1 actin filament-associated protein 1-like 2 isoform 19
NM_001351080.2 NP_001338009.1 actin filament-associated protein 1-like 2 isoform 20
NM_032550.4 NP_115939.1 actin filament-associated protein 1-like 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH2 domain binding IPI
IPI: Inferred from physical interaction
17412687 GOA
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
17412687 GOA
enables protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
17412687 GOA
Biological Process GO Annotation Evidence References Source
involved in inflammatory response IDA
IDA: Inferred from direct assay
17412687 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17412687 GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
17412687 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
17412687 GOA
involved in regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
17412687 GOA
involved in regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
17412687 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17412687 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AFAP1L2 Protein Structure

PH

PH: PH domain (181 - 269)

PH

PH: PH domain (365 - 439)

  • 0
  • 200
  • 400
  • 600
  • 818 a.a.
Protein Preferred Names Protein Names

actin filament-associated protein 1-like 2

  • AFAP1-like protein 2

AFAP1L2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84672 AFAP1L2 Antibody (YA4369) WB, FC, ELISA Human
HY-P84672A AFAP1L2 Antibody (YA4369)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Vesicoureteral Reflux

  • Vesico-Ureteral Reflux
Cartilage Cancer

  • Chondrogenic Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00426 AFAP1L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AFAP1L2 RGD RGD:1310668
Felis catus AFAP1L2 VGNC VGNC:59667
Bos taurus AFAP1L2 VGNC VGNC:25708
Canis familiaris AFAP1L2 VGNC VGNC:49824
Mus musculus AFAP1L2 MGD MGI:2147658
Macaca mulatta AFAP1L2 VGNC VGNC:69700
Others AFAP1L2 NCBI