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  5. Caspase-14 Antibody (YA3180)

Caspase-14 Antibody (YA3180)

Art. -Nr.: HY-P83435
COA
SDS
User Guide for Antibodies Technical Support

Caspase-14 Antibody (YA3180) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-14.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Beschreibung

  • Verweise

Beschreibung

Caspase-14 Antibody (YA3180) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-14.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molekulargewicht
Predicted band size: 28 kDa;
Observed band size: 28 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Caspase-14 aa101-155.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:2000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
FC
FC: Flow Cytometry
1:50-1:100
IP
IP: Immunoprecipitation
1:50
Sensitivity Endogenous Reinheit Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Background
Function：Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736)
Subcellular Localization：Cytoplasm; Nucleus
Expression：
Tissue_specificity:Expressed in keratinocytes above the basal layer of adult skin (from the spinous layer to the granular layer and stratum corneum) (protein level) . Expressed in keratinocytes of hair shafts and sebaceous glands (protein level) . Expressed at very low levels in psoriatic skin (PubMed:11175259) . The mature form p17/10 is expressed in the stratum corneum of the epidermis, and the intermediate form p20/p8 is expressed in the granular cells of the upper granular layer of the epidermis (PubMed:22825846) .

Induction:In undifferentiated keratinocytes under postconfluency growth conditions (in vitro) (PubMed:11175259) . By high glucose in retinal pigment epithelia cells (PubMed:25121097)
Subunit：Heterodimer of a large and a small subunit, both processed from the precursor; the mature active form is a p17/p10 dimer and the intermediate form a p20/p8 dimer
Database

Entrez Gene: 23581 Human ; 12365 Mouse ; 299587 Rat

SwissProt: P31944 Human ; O89094 Mouse ;

OMIM: 617320 Human

Research Field

Cell Biology
Synonyms
CASP14; Caspase-14; Caspase 14; MICE; CASP-14
Dokumentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)
Verweise

Caspase-14 Antibody (YA3180) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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