CASP14 - caspase 14 Gene

Also Known as ARCI12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23581

About CASP14

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,049,480-15,058,293 (from NCBI)

This gene has 2 transcripts (splice variants), 179 orthologues, 16 paralogues and is associated with 1 phenotype. Restricted expression toward skin (RPKM 223.1).

Summary

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This Caspase has been shown to be processed and activated by Caspase 8 and Caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related Apoptosis inducing ligand in vivo. The expression and processing of this Caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]

CASP14 Products (1)

mRNA Protein Name
NM_012114.3 NP_036246.1 caspase-14 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24872419 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23377137 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23377137 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP14 Protein Structure

Peptidase_C14

Peptidase_C14: Caspase domain (20 - 240)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

caspase-14

  • CASP-14

CASP14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CASP14 P31944 PSAP Homo sapiens P07602
Pull Down
24872419
Intra
CASP14 P31944 PSAP Homo sapiens P07602
PLA
24872419
Intra
CASP14 P31944 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
CASP14 P31944 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CASP14 Proteins

Cat. No. Product Name Accession Purity
HY-P7743 Caspase-14/CASP14 Protein, Human (His) P31944 (S2-Q242) ≥ 95%, as determined by reducing SDS-PAGE.

CASP14 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80045 Caspase-14 Antibody (YA558) WB, ICC/IF, IHC-P, FC, IP Human, Mouse
HY-P83435 Caspase-14 Antibody (YA3180) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Ichthyosis, Congenital, Autosomal Recessive 12

  • ARCI12
Autosomal Recessive Congenital Ichthyosis

  • Lamellar Ichthyosis

  • Congenital Ichthyosiform Erythroderma

  • Li

  • Congenital Nonbullous Ichthyosiform Erythroderma

  • Arci

  • Congenital Lamellar Ichthyosis

  • Nonbullous Congenital Ichthyosiform Erythroderma

  • Cie

  • Congenital Non-Bullous Ichthyosiform Erythroderma

  • Erythrodermic Ichthyosis

  • Nbcie

  • Ncie

  • Non-Bullous Congenital Ichthyosiform Erythroderma

  • Collodion Baby

  • Ichthyosis, Lamellar

  • Non Bullous Congenital Ichthyosiform Erythroderma

  • Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

  • Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

  • Collodion Baby Syndrome

  • Ichthyoses, Lamellar

  • Nbie

  • Nonbullous Ichthyosiform Erythroderma

  • Classic Lamellar Ichthyosis

  • Ichthyosiform Erythroderma Nonbullous Congenital

  • Ichthyosiform Erythroderma Congenital

  • Ichthyosis, Congenital, Autosomal Recessive

  • Ichthyosiform Erythroderma, Congenital

  • Collodion Fetus

  • Non-Bullous Ichthyosiform Erythroderma
Ichthyosis

  • Ichthyoses

  • Non-Syndromic Ichthyosis

  • Congenital Ichthyosis
Type 1 Diabetes Mellitus 17

  • Diabetes Mellitus, Insulin-Dependent, 17

  • Iddm17

  • Insulin-Dependent Diabetes Mellitus 17

  • TID17

  • Insulin-Dependent Diabetes Mellitus-17
Ichthyosis Vulgaris

  • Ichthyosis Simplex

  • Dominant Congenital Ichthyosiform Erythroderma

  • Common Ichthyosis

  • Fish Scale Disease

  • VI

  • Ichthyoses

  • Congenital Ichthyosis
Ichthyosis, Congenital, Autosomal Recessive 1

  • Collodion Fetus

  • Autosomal Recessive Congenital Ichthyosis 1

  • ARCI1

  • Ichthyosis Congenita

  • Lamellar Exfoliation Of Newborn

  • Desquamation Of Newborn

  • Ichthyosis Congenita Ii

  • Shcb

  • Icr2

  • Bathing Suit Ichthyosis

  • Li1

  • Self-Healing Collodion Baby

  • Ichthyosis, Congenital, Autosomal Recessive 1, With Bathing Suit Distribution

  • Collodion Baby, Self-Healing

  • Ichthyosis, Lamellar, 1, Formerly

  • Li1, Formerly

  • Ichthyosis Lamellar 1

  • Lamellar Ichthyosis, Type 1

  • Bsi

  • Autosomal Recessive Congenital Ichthyosis 1 With Bathing Suit Distribution

  • Autosomal Recessive Congenital Ichthyosis Tgm1-Related

  • Lamellar Ichthyosis 1

  • Non-Erythrodermic Ichthyosis

  • Ichthyosis, Congenital, Autosomal Recessive, Type 1

  • Congenital Ichthyosis
Ichthyosis, Congenital, Autosomal Recessive 4b

  • Harlequin Ichthyosis

  • Autosomal Recessive Congenital Ichthyosis 4b

  • Hi

  • Harlequin Fetus

  • ARCI4B

  • Ichthyosis Congenita, Harlequin Fetus Type

  • Harlequin Type Ichthyosis

  • 'Harlequin Fetus'

  • Harlequin Type Ichthyosis Congenita

  • Harlequin Type Ichthyosis Fetalis

  • Harlequin Baby Syndrome

  • Ichthyosis Congenita, Harlequin Type

  • Ichthyosis Fetalis, Harlequin Type

  • Ichthyosis Congenita Harlequin Fetus Type

  • Ichthyosis, Harlequin

  • Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Psoriasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-174458 MD-4251 Degrader / Unkown
HY-P11596 NOTA-Asp2-αvβ6L / Unkown
HY-RS01948 CASP14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20533 Casp14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27042 Casp14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CASP14 VGNC VGNC:38732
Macaca mulatta CASP14 VGNC VGNC:70542
Felis catus CASP14 VGNC VGNC:60380
Mus musculus CASP14 MGD MGI:1335092
Bos taurus CASP14 VGNC VGNC:26779
Rattus norvegicus CASP14 RGD RGD:1311781
Others CASP14 NCBI