CD1B Antibody (YA7109)
(Synonyms: CD1b, T-cell surface glycoprotein CD1b, CD1B)CD1B Antibody (YA7109) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD1B.
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Host:
Mouse
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Isotype:
IgG
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:400 | 1:10000 |
Product Details
CD1B Antibody (YA7109) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD1B.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 37kDa;
SwissProt: SwissProt: P29016
Purified recombinant fragment of human CD1B (AA: extra 18-303) expressed in E. Coli.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD1b is a group 1 CD1 antigen-presenting molecule that displays self and microbial lipid antigens to αβ and γδ T cells, thereby extending immune surveillance beyond peptide-based antigen recognition systems[1][2]. Mechanistically, CD1b contains the largest antigen-binding groove within the CD1 family, including interconnected A′, C′, F′, and T′ pockets that accommodate lipids with long alkyl chains and support presentation of structurally diverse mycobacterial and endogenous lipids[3][4]. Following intracellular trafficking through endosomal and lysosomal compartments, CD1b loads lipid antigens and forms complexes that activate CD1b-restricted T-cell responses[5][6]. In disease-relevant settings, CD1b participates in immune recognition of microbial lipids, particularly those derived from Mycobacterium tuberculosis, and also presents self phospholipids and gangliosides that have been linked to autoreactive T-cell responses[3][4]. Compared with related isoforms, CD1a and CD1c more closely reflect the overall cellular lipidome, whereas CD1b shows preferential association with sphingolipids and possesses a substantially larger antigen-binding cleft that enables presentation of longer lipid antigens[3][4]. This structural specialization distinguishes CD1b from CD1a, CD1c, and CD1d and supports its role in studying lipid antigen presentation, host-pathogen interactions, and CD1-restricted T-cell biology[1][3][6].
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Subcellular Localization
Cell membrane,Endosome membrane,Lysosome membrane
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Expression
Tissue_Specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues -
Isoforms & Post-Translational Modification
P29016 has two isomers: P29016-1: 36939 Da (predicted); P29016-2: 30740 Da (predicted).
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Subunit
Heterodimer with B2M (beta-2-microglobulin)
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SwissProt ID
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Synonyms
CD1b, T-cell surface glycoprotein CD1b, CD1B
Documentation
[1]. Chancellor A, et al. The versatility of the CD1 lipid antigen presentation pathway. Immunology. 2018 Jun;154(2):196-203. [Content Brief]
[2]. Van Rhijn I. Do antigen-presenting CD1a, et al. 2023 Oct;44(10):757-759. doi: 10.1016/j.it.2023.08.010. Epub 2023 Sep 18. PMID: 37730500. [Content Brief]
[3]. Van Kaer L, et al. Mechanisms and Consequences of Antigen Presentation by CD1. Trends Immunol. 2016 Nov;37(11):738-754. doi: 10.1016/j.it.2016.08.011. Epub 2016 Sep 9. PMID: 27623113; PMCID: PMC5159200. [Content Brief]
[4]. Szoke-Kovacs R, et al. Insights into the CD1 lipidome. Front Immunol. 2024;15:1462209.
[5]. Pereira CS, et al. Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients. Front Immunol. 2019 Jun 4;10:1264. [Content Brief]
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