CD31/PECAM-1 Antibody (YA9505)
(Synonyms: Pecam, PECAM 1, Pecam1, PECAM-1)
Based on 1 Customer Validation
CD31/PECAM-1 Antibody (YA9505) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD31/PECAM-1.
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Host:
Mouse
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Isotype:
IgG
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Application:
ICC/IF, IF-Tissue, IHC-P, FC
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Reactivity :
mouse, rat
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:50-500 | 1:50-500 | 1:100-500 | 1μg per 1*106 cells |
Product Details
CD31/PECAM-1 Antibody (YA9505) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD31/PECAM-1.
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Host Mouse
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Species Reactivitymouse, rat
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Calculated Molecular Weight Predicted band size: 130 kDa
A synthesized peptide derived from rat CD CD31/PECAM-1.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD31/PECAM-1 is a Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity). Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity). Modulates bradykinin receptor BDKRB2 activation (By similarity). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity). Induces susceptibility to atherosclerosis[1].
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Subcellular Localization
Cell membrane; Membrane raft; Cell junction
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Expression
Tissue_Specificity: Expressed in lung and platelets (at protein level). -
Isoforms & Post-Translational Modification
CD31/PECAM-1 has 4 isoforms, Q08481-1: amino acid length is 727, molecular weight is 81263 Da (predicted); Q08481-2: amino acid length is 697, molecular weight is 77917 Da (predicted); Q08481-3: amino acid length is 716, molecular weight is 80004 Da (predicted); Q08481-4: amino acid length is 626, molecular weight is 69823 Da (predicted).
Phosphorylated on Ser and Tyr residues by src kinases after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation. -
Subunit
Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction.
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SwissProt ID
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Synonyms
Pecam, PECAM 1, Pecam1, PECAM-1
Documentation
References
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