Pecam1 - platelet/endothelial cell adhesion molecule 1 Gene

Also Known as Cd31; Pecam; PECAM-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18613

Summary

Predicted to enable protein homodimerization activity; protein Phosphatase binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including Rho protein signal transduction; endothelial cell morphogenesis; and positive regulation of tyrosine phosphorylation of STAT protein. Located in several cellular components, including cell-cell contact zone; external side of plasma membrane; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in coronary artery disease (multiple); lung non-small cell carcinoma; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Pecam1 Products (4)

mRNA	Protein	Name
NM_001032378.2	NP_001027550.1	platelet endothelial cell adhesion molecule isoform 2 precursor
NM_001305157.1	NP_001292086.1	platelet endothelial cell adhesion molecule isoform 3 precursor
NM_001305158.1	NP_001292087.1	platelet endothelial cell adhesion molecule isoform 4 precursor
NM_008816.3	NP_032842.2	platelet endothelial cell adhesion molecule isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10562326	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	12890700	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	17563397	MGI
acts upstream of or within cell adhesion	IDA IDA: Inferred from direct assay	20724702	MGI
acts upstream of or within endothelial cell migration	IMP IMP: Inferred from mutant phenotype	17563397	MGI
acts upstream of or within endothelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	17563397	MGI
acts upstream of or within endothelial cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	17563397	MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	11254359	MGI
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12890700	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	12890700	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell periphery	IDA IDA: Inferred from direct assay	21464233	MGI
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	20724702	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	20724702	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16455951	MGI
located in membrane	IDA IDA: Inferred from direct assay	16691571	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	12890700	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12736726	MGI
located in smooth muscle contractile fiber	IDA IDA: Inferred from direct assay	18332105	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
platelet endothelial cell adhesion molecule

Recombinant Pecam1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72737	CD31/PECAM-1 Protein, Mouse (HEK293, His)	Q08481 (E18-K590)	≥ 95%, as determined by reducing SDS-PAGE.

Pecam1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810161	CD31/PECAM-1 Antibody (YA9505)	ICC/IF, IF-Tissue, IHC-P, FC	mouse, rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3444	CD31		99.33%	Unkown
HY-P3444A	CD31 TFA		/	Unkown
HY-RS10315	PECAM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174546	Human PECAM1 mRNA		/	Unkown
HY-RS17929	Pecam1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24399	Pecam1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990277	Anti-Mouse CD31/PECAM-1 Antibody (390)	Inhibitor	≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pecam1	NCBI	NCBI:5175