CD369 Antibody (YA4466)(PBS only)
(Synonyms: CLEC7A; BGR; CANDF4; SCARE2; DECTIN1; CLECSF12)CD369 Antibody (YA4466) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD369.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD369 Antibody (YA4466) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD369.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 28 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 28 kDa
Purified recombinant fragment of human CD369 (AA: extra 66-247) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD369 is a Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans[1][2][3].
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein; Cytoplasm; Cytoplasm; Cytoplasm
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Expression
Tissue_specificity:Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta
Induction:Up-regulated during differentiation from monocytes into dendritic cells -
Isoforms & Post-Translational Modification
Q9BXN2 has 10 isomers: Q9BXN2-1: 27627 Da (predicted); Q9BXN2-2: 22563 Da (predicted); Q9BXN2-3: 21065 Da (predicted); Q9BXN2-4: 21130 Da (predicted); Q9BXN2-5: 19218 Da (predicted); Q9BXN2-6: 14787 Da (predicted); Q9BXN2-7: 16000 Da (predicted); Q9BXN2-8: 5164 Da (predicted); Q9BXN2-9: 8363 Da (predicted); Q9BXN2-10: 13138 Da (predicted).
Phosphorylated on tyrosine residues in response to beta-glucan binding -
Subunit
Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens. Interacts with CD37; this interaction controls CLEC7A-mediated IL-6 production (PubMed:17182550)
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SwissProt ID
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Synonyms
CLEC7A; BGR; CANDF4; SCARE2; DECTIN1; CLECSF12
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