CLEC7A - C-type lectin domain containing 7A Gene

Also Known as BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64581

About CLEC7A

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,116,777-10,130,304 (from NCBI)

This gene has 13 transcripts (splice variants), 227 orthologues, 23 paralogues and is associated with 3 phenotypes. Broad expression in appendix (RPKM 22.1), bone marrow (RPKM 11.8) and 17 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and Plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to Other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

CLEC7A Products (6)

mRNA	Protein	Name
NM_022570.5	NP_072092.2	C-type lectin domain family 7 member A isoform b
NM_197947.3	NP_922938.1	C-type lectin domain family 7 member A isoform a
NM_197948.3	NP_922939.1	C-type lectin domain family 7 member A isoform c
NM_197949.3	NP_922940.1	C-type lectin domain family 7 member A isoform d
NM_197950.3	NP_922941.1	C-type lectin domain family 7 member A isoform e
NM_197954.3	NP_922945.1	C-type lectin domain family 7 member A isoform f

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables (1->3)-beta-D-glucan binding	IDA IDA: Inferred from direct assay	22267217	GOA
enables carbohydrate binding	IDA IDA: Inferred from direct assay	11567029	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	11567029	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell recognition	IDA IDA: Inferred from direct assay	11567029	GOA
involved in cellular response to molecule of fungal origin	IDA IDA: Inferred from direct assay	22267217	GOA
involved in detection of fungus	IDA IDA: Inferred from direct assay	19358895	GOA
involved in detection of molecule of fungal origin	IDA IDA: Inferred from direct assay	19358895	GOA
involved in phagocytosis, recognition	IDA IDA: Inferred from direct assay	11567029	GOA
involved in positive regulation of cell maturation	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24721111	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24721111	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22267217	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	22267217	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	22267217	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	25251945	GOA
involved in positive regulation of killing of cells of another organism	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of lymphocyte activation	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	25251945	GOA
involved in positive regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	22267217	GOA
involved in positive regulation of respiratory burst	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of superoxide anion generation	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	24721111	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	24721111	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24721111	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	25251945	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC7A Protein Structure

Lectin_C

0
100
200
247 a.a.

Protein Preferred Names	Protein Names
C-type lectin domain family 7 member A	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12

CLEC7A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLEC7A	Q9BXN2	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	25416956
Intra	CLEC7A	Q9BXN2	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	q9brl5_human	Homo sapiens	Q9BRL5	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	q9brl5_human	Homo sapiens	Q9BRL5	Y2H Prey Pooling	25416956
Intra	CLEC7A	Q9BXN2	q9brl5_human	Homo sapiens	Q9BRL5	Validated Y2H	25416956
Intra	CLEC7A	Q9BXN2	FAM3A	Homo sapiens	Q9BU27	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	TMPRSS4	Homo sapiens	Q9NRS4-3	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	NINJ2	Homo sapiens	Q9NZG7	Y2H Prey Pooling	25416956
Intra	CLEC7A	Q9BXN2	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	25416956
Intra	CLEC7A	Q9BXN2	OCLN	Homo sapiens	Q16625	Validated Y2H	25416956
Intra	CLEC7A	Q9BXN2	KTN1	Homo sapiens	Q86UP2	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	KTN1	Homo sapiens	Q86UP2	Validated Y2H	25416956
Intra	CLEC7A	Q9BXN2	PTTG1IP	Homo sapiens	P53801	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	PTTG1IP	Homo sapiens	P53801	Y2H Prey Pooling	25416956
Intra	CLEC7A	Q9BXN2	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	25416956
Intra	CLEC7A	Q9BXN2	SMIM3	Homo sapiens	Q9BZL3	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	SMIM3	Homo sapiens	Q9BZL3	Y2H Prey Pooling	25416956
Intra	CLEC7A	Q9BXN2	BNIP3	Homo sapiens	Q12983	Y2H Prey Pooling	25416956
Intra	CLEC7A	Q9BXN2	BNIP3	Homo sapiens	Q12983	Validated Y2H	25416956
Intra	CLEC7A	Q9BXN2	BNIP3	Homo sapiens	Q12983	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	BNIP3L	Homo sapiens	O60238	Validated Y2H	25416956
Intra	CLEC7A	Q9BXN2	BNIP3L	Homo sapiens	O60238	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	31515488
Intra	CLEC7A	Q9BXN2	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	25416956
Intra	CLEC7A	Q9BXN2	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	25416956
Intra	CLEC7A	Q9BXN2	IL1RL1	Homo sapiens	Q01638	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC7A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70101	Dectin-1/CLEC7A Protein, Human (HEK293, Fc)	Q9BXN2-1 (T66-M247)	≥ 95%, as determined by reducing SDS-PAGE.

CLEC7A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84769	CD369 Antibody (YA4466)	ICC/IF, FC, ELISA	Human
HY-P84769A	CD369 Antibody (YA4466)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Candidiasis, Familial, 4	Familial Chronic Mucocutaneous Candidiasis CANDF4 Candidiasis, Familial Chronic Mucocutaneous Candidiasis, Familial, 4, Autosomal Recessive Candidiasis Familial Chronic Mucocutaneous Chronic Mucocutaneous Candidiasis 4 Candidiasis, Familial, Type 4 Candidiasis, Familial, 2
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Trichosporonosis
Fungal Infectious Disease	Mycoses Mycosis
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Primary Systemic Mycosis
Vulvovaginal Candidiasis	Candidiasis Of Vulva And Vagina Candidiasis, Vulvovaginal Candidal Vulvovaginitis Candidal: Cervix Monilial Vulvovaginitis Candidiasis Vulvovaginal
Subcutaneous Mycosis	Subcutaneous Fungal Disease
Invasive Aspergillosis	Aspergillosis Invasive
Tinea Profunda	Deep Seated Dermatophytosis Granuloma Trichophyticum Majocchi'S Granuloma
Dermatophytosis	Tinea Dermatophytosis, Unspecified Ringworm Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton Cutaneous Mycosis Dermal Mycosis Superficial Mycosis, Unspecified Fungus Infection Of Skin Skin Mycosis Dermatitis Fungoid Fungal Dermatitis Fungal Dermatosis Mycotic Infection Of Skin
Phaeohyphomycosis	Infection By Dematiacious Fungi Phaehyphomycosis Phaeomycosis Pheohyphomycosis Infection By Dematiacious Fungi [Phaehyphomycosis] Dematiaceous Fungal Infection
Vaginal Disease	Vaginal Diseases
Tinea Corporis	Dermatophytosis Of The Body Dermatophytosis Of The Trunk
Coccidioidomycosis	Valley Fever Primary Extrapulmonary Coccidioidomycosis Coccidioides Immitis Infection Coccidiosis Coccidioides Infection Coccidioidomycosis, Unspecified San Joaquin Fever California Disease Desert Fever Desert Rheumatism San Joaquin Valley Fever Enteric Coccidiosis Primary Pulmonary Coccidioidomycosis Acute Coccidioidomycosis Posadas Wernicke Disease
Blastomycosis	Gilchrist'S Disease North American Blastomycosis Blastomyces Dermatitidis Infection Blastomycotic Infection Infection By Blastomyces Dermatitidis Gilchrist Disease Chicago Disease Chicago Disease Or Disorder Blastomycosis, Unspecified Blastomyces Infection
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly
Tinea Pedis	Athlete'S Foot Dermatophytosis Of Foot Ringworm Of Foot Moccasin Foot
Superficial Mycosis	Piedra Steroid-Modified Tinea Infection
Neonatal Candidiasis	Neonatal Candida Infection Neonatal Monilia Infection Neonatal Moniliasis
Pneumocystosis	Pneumocystis Jirovecii Pneumonia Pneumocystis Carinii Pneumonia Pneumocystis Pneumonia Pulmonary Pneumocystosis PCP Pneumocystosis Pneumonia Pneumonia Pneumocystis Carinii Pneumonia, Pneumocystis Pneumocystis Jiroveci Pneumonia
Chromoblastomycosis	Chromomycosis Mossy Foot Disease Verrucous Dermatitis Fonseca Disease Pedroso Disease Drechslera Hawaiiensis Drechslera Infection
Sporotrichosis	Rose Gardener'S Disease
Cutaneous Candidiasis	Candidiasis, Cutaneous
Denture Stomatitis	Stomatitis, Denture Denture Sore Mouth
Penicilliosis
Tinea Imbricata	Kerion Celsi Trichophyton Infection Tinea Imbricata, Susceptibility To Susceptibility To Tinea Imbricata Tinea Capitis Profunda Trichophytia Profunda Barbae Trichophytia Profunda Capitis Tinea Capitis
Tinea Capitis	Dermatophytosis Of Scalp Scalp Ringworm Dermatophytosis Of Scalp Or Beard Tinea Capitis Due To Trichophyton Rubrum Trichophyton Rubrum Tinea Capitis
White Piedra	Tinea Blanca Trichosporosis Nodosa
Cryptococcosis	Cryptococcus Neoformans Infection Torulosis Busse-Buschke'S Disease Cryptococcal Infection European Cryptococcosis Torula Infection By Cryptococcus Neoformans Cryptococcosis Infection European Blastomycosis European Blastomycotic Infection European Blastomycoses Infection Torula Histolytica Infection
Oral Candidiasis	Thrush Candidiasis Of Mouth Oral Moniliasis Thrush, Oral Candidiasis, Oral Oral Thrush Candidiasis Equine Thrush
Mucormycosis	Zygomycosis Disseminated Mucormycosis Absidia Infection Absidia Mucoromycosis Cunninghamella Infection Cunninghamella Mucoromycosis Infection By Absidia Spp Infection By Rhizopus Spp Mucor Infection Mucor Mucoromycosis Infection By Mucor Spp Rhizopus Infection Rhizopus Mucoromycosis Infection By Cunninghamella Spp Phycomycosis Nos
Allergic Bronchopulmonary Aspergillosis	Aspergillosis, Allergic Bronchopulmonary Abpa Allergic Bronchopulmonary Mycosis Hinson-Pepys Disease Pulmonary Aspergillus Disease Allergic Aspergillosis Aspergillosis Allergic Bronchopulmonary
Pityriasis Versicolor	Tinea Versicolor Infection By Pityrosporum Furfur
Histoplasmosis	Darling Disease Reticuloendotheliosis, X-Linked Infection By Histoplasma Capsulatum Histoplasma Infection Reticuloendothelial Cytomycosis Cytomycosis Darling Histoplasmosis African Histoplasmosis Histoplasmosis Duboisii
Hyper Ige Recurrent Infection Syndrome 1	Job Syndrome Hyper-Ige Recurrent Infection Syndrome 1 Hyperimmunoglobulin E Syndrome Job'S Syndrome Recurring Cold Staphylococcal Abscesses Ige Syndromes Buckley Syndrome Hie - [Hyperimmunoglobulin E] Syndrome Job-Buckley Syndrome Quie-Hill Syndrome
Fungal Meningitis	Meningitis, Fungal Mycotic Meningitis
Autoimmune Polyendocrine Syndrome Type 1	Whitaker Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Autoimmune Polyglandular Syndrome I Polyglandular Type I Autoimmune Syndrome
Autoimmune Polyendocrine Syndrome	Autoimmune Polyendocrinopathy Autoimmune Polyglandular Failure Autoimmune Polyglandular Syndrome Polyendocrinopathies, Autoimmune Lloyd'S Syndrome Aps Polyendocrinopathies Autoimmune Polyendocrine Autoimmunity Syndrome Lloyd Syndrome Polyglandular Autoimmune Deficiency Progressive Pluriglandular Insufficiency Pluriglandular Autoimmune Atrophy Pluriglandular Autoimmune Syndrome Thyroid-Adrenocortical Insufficiency Syndrome
Neuroaspergillosis
Fusariosis	Fusarium Infection
Vulvovaginitis	Vulvo-Vaginitis
Cryptococcal Meningitis	Meningitis, Cryptococcal Meningitis Cryptococcal
Esophageal Candidiasis	Candidiasis Of The Esophagus Candida Esophagitis Candidal Esophagitis Esophageal Moniliasis Esophageal Thrush
Corneal Ulcer	Cornea Ulcer Ulcerative Keratitis Corneal Ulcer Nos
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147295	Odetiglucan	Agonist	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS17778	Clec7a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02800	CLEC7A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24245	Clec7a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990374	Anti-CLEC7A Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CLEC7A	VGNC	VGNC:97753
Mus musculus	CLEC7A	MGD	MGI:1861431
Felis catus	CLEC7A	VGNC	VGNC:60955
Rattus norvegicus	CLEC7A	RGD	RGD:1565140
Bos taurus	CLEC7A	VGNC	VGNC:58597
Canis familiaris	CLEC7A	VGNC	VGNC:39335
Others	CLEC7A	NCBI