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Cat. No.: HY-P811361

COPS7B Antibody

(Synonyms: CSN7B, COPS7B, COP9 signalosome complex subunit 7b, SGN7b, Signalosome subunit 7b, JAB1-containing signalosome subunit 7b)

COPS7B Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to COPS7B.

For research use only. We do not sell to patients.

Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	FC FC: Flow Cytometry
Dilution Ratio	1:1000-2000	1:100-200	1:10-30

Description

COPS7B Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to COPS7B.

Host Rabbit
Clonality Polyclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 30 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 29 kDa

Immunogen

Synthetic peptide corresponding to the Central region of human COPS7B.

Sensitivity

Endogenous

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Soulution
Formulation

Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

COPS7B is a Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Subcellular Localization

Cytoplasm; Nucleus
Subunit

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1.
SwissProt ID

Q9H9Q2
Gene ID

64708 [NCBI]
Synonyms

CSN7B, COPS7B, COP9 signalosome complex subunit 7b, SGN7b, Signalosome subunit 7b, JAB1-containing signalosome subunit 7b