CXCR3 Antibody (YA4052)(PBS only)
(Synonyms: CXCR3; GPR9; MigR; CD182; Mig-R; CKR-L2; CMKAR3; IP10-R)CXCR3 Antibody (YA4052) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CXCR3.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CXCR3 Antibody (YA4052) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CXCR3.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 40.7 kDa
Purified recombinant fragment of human CD183 (AA: extra mix) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling; Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis; Mediates the activity of CXCL11
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Isomer 1 and isomer 2 are primarily expressed in the heart, kidneys, liver, and skeletal muscle. Isomer 1 is also expressed in the placenta. Isomer 2 is expressed in endothelial cells. It is also expressed in T cells (protein level) . -
Isoforms & Post-Translational Modification
P49682 has 3 isomers: P49682-1: 40660 Da (predicted); P49682-2: 45523 Da (predicted); P49682-3: 28715 Da (predicted).
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction;N-glycosylated -
Subunit
Homomer. Forms heteromers with ACKR4
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SwissProt ID
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Synonyms
CXCR3; GPR9; MigR; CD182; Mig-R; CKR-L2; CMKAR3; IP10-R
Documentation
References
[1]. Huo R, et al. CXCR3 inhibitors for therapeutic interventions: current status and perspectives. Front Pharmacol. 2025 Jul 25;16:1556196. [Content Brief]
[2]. Boyé K, et al. Ligand activation induces different conformational changes in CXCR3 receptor isoforms as evidenced by plasmon waveguide resonance (PWR). Sci Rep. 2017 Sep 6;7(1):10703. [Content Brief]
[3]. Caccuri F, et al. The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3). Int J Mol Sci. 2019 Oct 24;20(21):5287. [Content Brief]
[4]. Eiger DS, et al. Location bias contributes to functionally selective responses of biased CXCR3 agonists. Nat Commun. 2022 Oct 4;13(1):5846. [Content Brief]
[5]. Wang X, et al. Effects of CXCL4/CXCR3 on the lipopolysaccharide-induced injury in human umbilical vein endothelial cells. J Cell Physiol. 2019 Dec;234(12):22378-22385. [Content Brief]
[6]. Torraca V, et al. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Dis Model Mech. 2015 Mar;8(3):253-69. [Content Brief]
[7]. Wu Q, et al. Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. Mol Cancer. 2012 Jan 11;11:3. [Content Brief]
[8]. Sheng W, et al. Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood-brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage. Cell Death Discov. 2025 Aug 8;11(1):373. [Content Brief]
[9]. Lee J, et al. CXCR3-CXCL11 Signaling Restricts Angiogenesis and Promotes Pericyte Recruitment. Arterioscler Thromb Vasc Biol. 2024 Dec;44(12):2577-2595. [Content Brief]
[10]. Huang YV, et al. Novel Therapeutic Approach Targeting CXCR3 to Treat Immunotherapy Myocarditis. Circ Res. 2025 Feb 28;136(5):473-490. [Content Brief]
[11]. Bodnar RJ, et al. Differential regulation of pericyte function by the CXC receptor 3. Wound Repair Regen. 2015 Nov-Dec;23(6):785-96. [Content Brief]
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