2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. DAPK2 Antibody (YA2643)

DAPK2 Antibody (YA2643) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DAPK2.

For research use only. We do not sell to patients.

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50 μL In-stock
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

DAPK2 Antibody (YA2643) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DAPK2.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 43 kDa;
Observed band size: 43 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human DAPK2 aa19-32.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:5000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
FC
FC: Flow Cytometry
1:200-1:1000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421); Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death
Subcellular Localization：Cytoplasm; Cytoplasmic vesicle, autophagosome lumen
Expression：
Tissue_specificity:Expressed in neutrophils and eosinophils (PubMed:24163421) . Isoform 2 is expressed in embryonic stem cells (at protein level) . Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle

Induction:Up-regulated during granulocytic maturation (PubMed:17347302, PubMed:24163421)
Isoforms & Post-Translational Modification：Q9UIK4 has 2 isomers: Q9UIK4-1: 42898 Da (predicted); Q9UIK4-2: 55931 Da (predicted).
Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors
Subunit：Homodimer in its autoinhibited state. Isoform 2 but not isoform 1 can interact with ATF4. Interacts with 14-3-3 proteins YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN
Database

Entrez Gene: 300799 Rat

Research Field

Cell Biology
Synonyms
DAPK2; Death-associated protein kinase 2; DAP kinase 2; DAP-kinase-related protein 1; DRP-1
Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

DAPK2 Antibody (YA2643) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DAPK2 Antibody (YA2643)
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HY-P82898
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