DAPK2 - death associated protein kinase 2 Gene

Also Known as DRP1; DRP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23604

About DAPK2

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:63,907,036-64,046,485 (from NCBI)

This gene has 13 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues.

Summary

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell Apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

DAPK2 Products (20)

mRNA Protein Name
NM_001363730.2 NP_001350659.1 death-associated protein kinase 2 isoform 2
NM_001384997.1 NP_001371926.1 death-associated protein kinase 2 isoform 3
NM_001384998.1 NP_001371927.1 death-associated protein kinase 2 isoform 4
NM_001384999.1 NP_001371928.1 death-associated protein kinase 2 isoform 5
NM_001385000.1 NP_001371929.1 death-associated protein kinase 2 isoform 6
NM_001395279.1 NP_001382208.1 death-associated protein kinase 2 isoform 7
NM_001395281.1 NP_001382210.1 death-associated protein kinase 2 isoform 8
NM_001395282.1 NP_001382211.1 death-associated protein kinase 2 isoform 4
NM_001395283.1 NP_001382212.1 death-associated protein kinase 2 isoform 8
NM_001395284.1 NP_001382213.1 death-associated protein kinase 2 isoform 9
NM_001395285.1 NP_001382214.1 death-associated protein kinase 2 isoform 10
NM_001395286.1 NP_001382215.1 death-associated protein kinase 2 isoform 11
NM_001395287.1 NP_001382216.1 death-associated protein kinase 2 isoform 11
NM_001395288.1 NP_001382217.1 death-associated protein kinase 2 isoform 12
NM_001395289.1 NP_001382218.1 death-associated protein kinase 2 isoform 9
NM_001395290.1 NP_001382219.1 death-associated protein kinase 2 isoform 13 precursor
NM_001395291.1 NP_001382220.1 death-associated protein kinase 2 isoform 14
NM_001395292.1 NP_001382221.1 death-associated protein kinase 2 isoform 9
NM_001395293.1 NP_001382222.1 death-associated protein kinase 2 isoform 15
NM_014326.5 NP_055141.2 death-associated protein kinase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10376525 GOA
enables calmodulin binding IDA
IDA: Inferred from direct assay
10376525 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
10629061 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21408167 GOA
Biological Process GO Annotation Evidence References Source
involved in anoikis IMP
IMP: Inferred from mutant phenotype
18957423 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
10376525 GOA
involved in positive regulation of eosinophil chemotaxis IMP
IMP: Inferred from mutant phenotype
24163421 GOA
involved in positive regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
24163421 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10376525 GOA
involved in regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
10376525 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10376525 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAPK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (23 - 285)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

death-associated protein kinase 2

  • DAP kinase 2

DAPK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DAPK2 Q9UIK4 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
DAPK2 Q9UIK4 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra
DAPK2 Q9UIK4 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
DAPK2 Q9UIK4 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
DAPK2 Q9UIK4 CCDC91 Homo sapiens Q7Z6B0-2
Y2H Prey Pooling
32296183
Intra
DAPK2 Q9UIK4 CCDC91 Homo sapiens Q7Z6B0-2
Y2H Array
32296183
Intra
DAPK2 Q9UIK4 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
DAPK2 Q9UIK4 DAPK2 Homo sapiens Q9UIK4
GMS
11230133
Intra
DAPK2 Q9UIK4 DAPK2 Homo sapiens Q9UIK4
Anti Tag CoIP
10629061
Cross: Cross-species interaction Intra: Intraspecies interaction

DAPK2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82898 DAPK2 Antibody (YA2643) WB, IHC-P, FC Human, Mouse, Rat
HY-P82898A DAPK2 Antibody (YA2643)(PBS only) WB, IHC-P, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease Type 2a2b

  • Severe Early-Onset Axonal Neuropathy Due To Mfn2 Deficiency

  • Ar-Cmt2, Ouvrier Type

  • Autosomal Recessive Charcot-Marie-Tooth Disease, Ouvrier Type

  • Seoan Due To Mfn2 Deficiency

  • Charcot-Marie-Tooth Disease, Axonal, Type 2a2b

  • Cmt2a2b

  • Charcot-Marie-Tooth Disease, Type 2a2b
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178967 DRAK1/2-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DAPK2 VGNC VGNC:55109
Felis catus DAPK2 VGNC VGNC:80992
Macaca mulatta DAPK2 VGNC VGNC:71733
Mus musculus DAPK2 MGD MGI:1341297
Canis familiaris DAPK2 VGNC VGNC:59108
Rattus norvegicus DAPK2 RGD RGD:1304708
Others DAPK2 NCBI