DAPK2 - death associated protein kinase 2 Gene

Homo sapiens

Also known as DRP1; DRP-1

Gene ID: 23604 | Gene type: protein coding

About DAPK2

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:63,907,036-64,046,485 (from NCBI)

This gene has 13 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues.

Summary

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell Apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

DAPK2 Products(20)

mRNA	Protein	Name
NM_001363730.2	NP_001350659.1	death-associated protein kinase 2 isoform 2
NM_001384997.1	NP_001371926.1	death-associated protein kinase 2 isoform 3
NM_001384998.1	NP_001371927.1	death-associated protein kinase 2 isoform 4
NM_001384999.1	NP_001371928.1	death-associated protein kinase 2 isoform 5
NM_001385000.1	NP_001371929.1	death-associated protein kinase 2 isoform 6
NM_001395279.1	NP_001382208.1	death-associated protein kinase 2 isoform 7
NM_001395281.1	NP_001382210.1	death-associated protein kinase 2 isoform 8
NM_001395282.1	NP_001382211.1	death-associated protein kinase 2 isoform 4
NM_001395283.1	NP_001382212.1	death-associated protein kinase 2 isoform 8
NM_001395284.1	NP_001382213.1	death-associated protein kinase 2 isoform 9
NM_001395285.1	NP_001382214.1	death-associated protein kinase 2 isoform 10
NM_001395286.1	NP_001382215.1	death-associated protein kinase 2 isoform 11
NM_001395287.1	NP_001382216.1	death-associated protein kinase 2 isoform 11
NM_001395288.1	NP_001382217.1	death-associated protein kinase 2 isoform 12
NM_001395289.1	NP_001382218.1	death-associated protein kinase 2 isoform 9
NM_001395290.1	NP_001382219.1	death-associated protein kinase 2 isoform 13 precursor
NM_001395291.1	NP_001382220.1	death-associated protein kinase 2 isoform 14
NM_001395292.1	NP_001382221.1	death-associated protein kinase 2 isoform 9
NM_001395293.1	NP_001382222.1	death-associated protein kinase 2 isoform 15
NM_014326.5	NP_055141.2	death-associated protein kinase 2 isoform 1

DAPK2 Protein Structure

Pkinase

0
100
200
300
370 a.a.

Protein Preferred Names

Protein Names

death-associated protein kinase 2

DAP kinase 2

Related Diseases

Diseases

Alias

Charcot-Marie-Tooth Disease Type 2a2b

Severe Early-Onset Axonal Neuropathy Due To Mfn2 Deficiency	Ar-Cmt2, Ouvrier Type
Autosomal Recessive Charcot-Marie-Tooth Disease, Ouvrier Type	Seoan Due To Mfn2 Deficiency
Charcot-Marie-Tooth Disease, Axonal, Type 2a2b	Cmt2a2b
Charcot-Marie-Tooth Disease, Type 2a2b

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131909	CJ-2360	Inhibitor	/	Unkown
HY-RS03528	DAPK2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DAPK2	VGNC	VGNC:55109
Felis catus	DAPK2	VGNC	VGNC:80992
Macaca mulatta	DAPK2	VGNC	VGNC:71733
Mus musculus	DAPK2	MGD	MGI:1341297
Canis familiaris	DAPK2	VGNC	VGNC:59108
Rattus norvegicus	DAPK2	RGD	RGD:1304708
Others	DAPK2	NCBI

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