delta Opioid Receptor Antibody (YA3117)
(Synonyms: Delta type opioid receptor; Delta type opioid receptor DOR1; DOR 1; mDOR; Nbor; Opioid receptor delta 1; OPRD 1)delta Opioid Receptor Antibody (YA3117) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to delta Opioid Receptor.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
delta Opioid Receptor Antibody (YA3117) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to delta Opioid Receptor.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 40 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 40 kDa
Entrez Gene: 4985 Human ; 18386 Mouse ; 24613 Rat
SwissProt: P41143 Human ; P32300 Mouse ; P33533 Rat
OMIM: 165195 Human
A synthesized peptide derived from human OPRD1 aa1-32.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
delta Opioid Receptor is a G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine
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Subcellular Localization
Cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Detected in oocytes (at protein level) . Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes -
Subunit
May form homooligomers. Forms a heterodimer with OPRM1 (By similarity). Interacts with GPRASP1 (PubMed:12142540, PubMed:15086532). Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (By similarity)
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SwissProt ID
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Synonyms
Delta type opioid receptor; Delta type opioid receptor DOR1; DOR 1; mDOR; Nbor; Opioid receptor delta 1; OPRD 1
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Research Field
Neuroscience
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