DYNLL1 Antibody (YA2724)(PBS only)
(Synonyms: LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1)DYNLL1 Antibody (YA2724) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DYNLL1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:200-1:500 | 1:100-1:200 | 1:200-1:2000 | 1:20-1:50 |
Product Details
DYNLL1 Antibody (YA2724) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DYNLL1.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 10 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 10 kDa
A synthetic peptide of human DYNLL1
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DYNLL1 acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins. Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection. In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity[1][2][3][4][5][6].
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Subcellular Localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome; Cytoplasm, cytoskeleton; Nucleus; Mitochondrion
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Expression
Tissue_specificity:Ubiquitous (PubMed:8628263) . Expressed in testis (PubMed:22965910)
Induction:Up-regulated by ATMIN, PAK1 and estrogen -
Subunit
Homodimer (PubMed:18084006, PubMed:18650427). Monomer; the monomeric form is incapable of binding to target proteins (PubMed:18084006, PubMed:18650427).
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SwissProt ID
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Synonyms
LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1
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Research Field
Cell Biology
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