DYNLL1 - dynein light chain LC8-type 1 Gene

Homo sapiens

Also known as LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1

Gene ID: 8655 | Gene type: protein coding

About DYNLL1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,469,842-120,498,493 (from NCBI)

This gene has 11 transcripts (splice variants), 166 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 141.7), esophagus (RPKM 133.4) and 25 other tissues.

Summary

Cytoplasmic dyneins are large Enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a LIGHT chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

DYNLL1 Products(3)

mRNA	Protein	Name
NM_001037494.2	NP_001032583.1	dynein light chain 1, cytoplasmic
NM_001037495.2	NP_001032584.1	dynein light chain 1, cytoplasmic
NM_003746.3	NP_003737.1	dynein light chain 1, cytoplasmic

DYNLL1 Protein Structure

Dynein_light

0
89 a.a.

Protein Preferred Names

Protein Names

dynein light chain 1, cytoplasmic

8 kDa dynein light chain

Recombinant DYNLL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70048	PIN/DYNLL1 Protein, Human (His)	P63167 (M1-G89)	≥95%

Related Diseases

Diseases

Alias

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Prostate Carcinoma In Situ

Carcinoma In Situ Of Prostate	Grade Iii Pin
Pin Iii

Breast Adenoid Cystic Carcinoma

Adenoid Cystic Breast Carcinoma	Adenoid Cystic Carcinoma Of Breast
Mammary Adenocystic Carcinoma

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy	Jeune Syndrome
Asphyxiating Thoracic Dysplasia	Short-Rib Thoracic Dysplasia With Or Without Polydactyly
Thoracic Pelvic Phalangeal Dystrophy	Asphyxiating Thoracic Chondrodystrophy
Atd	Chondroectodermal Dysplasia-Like Syndrome
Infantile Thoracic Dystrophy	Jeune Thoracic Dysplasia
Thoracic Asphyxiant Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Short-Rib Thoracic Dysplasia Without Polydactyly	Asphyxiating Thoracic Dystrophy Of The Newborn
Asphyxiating Thorax Dystrophy

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04088	DYNLL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DYNLL1	MGD	MGI:1861457
Canis familiaris	DYNLL1	VGNC	VGNC:40150
Rattus norvegicus	DYNLL1	RGD	RGD:619866
Felis catus	DYNLL1	VGNC	VGNC:107702
Macaca mulatta	DYNLL1	VGNC	VGNC:99924
Others	DYNLL1	NCBI

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