DYNLL1 - dynein light chain LC8-type 1 Gene

Also Known as LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8655

About DYNLL1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,469,842-120,498,493 (from NCBI)

This gene has 11 transcripts (splice variants), 166 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 141.7), esophagus (RPKM 133.4) and 25 other tissues.

Summary

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

DYNLL1 Products (3)

mRNA Protein Name
NM_001037494.2 NP_001032583.1 dynein light chain 1, cytoplasmic
NM_001037495.2 NP_001032584.1 dynein light chain 1, cytoplasmic
NM_003746.3 NP_003737.1 dynein light chain 1, cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables deoxyribonuclease inhibitor activity IDA
IDA: Inferred from direct assay
30464262 GOA
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
30464262 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14607844 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA strand resection involved in replication fork processing IDA
IDA: Inferred from direct assay
30464262 GOA
involved in negative regulation of phosphorylation IDA
IDA: Inferred from direct assay
18579519 GOA
Cellular Component GO Annotation Evidence References Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
8628263 GOA
part of cytoplasmic dynein complex IDA
IDA: Inferred from direct assay
25830415 GOA
located in cytoskeleton IDA
IDA: Inferred from direct assay
20921139 GOA
part of dynein complex IPI
IPI: Inferred from physical interaction
24986880 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
20133940 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
20133940 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15891768 GOA
is active in site of double-strand break IDA
IDA: Inferred from direct assay
37696958 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLL1 Protein Structure

Dynein_light

Dynein_light: Dynein light chain type 1 (1 - 89)

  • 0
  • 89 a.a.
Protein Preferred Names Protein Names

dynein light chain 1, cytoplasmic

  • 8 kDa dynein light chain

DYNLL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DYNLL1 P63167 AMOTL2 Homo sapiens Q9Y2J4-4
Validated Y2H
25416956
Intra
DYNLL1 P63167 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Array
25416956
Intra
DYNLL1 P63167 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Prey Pooling
25416956
Intra
DYNLL1 P63167 IQUB Homo sapiens Q8NA54
Y2H Prey Pooling
25416956
Intra
DYNLL1 P63167 IQUB Homo sapiens Q8NA54
Y2H Array
25416956
Intra
DYNLL1 P63167 CCDC28A Homo sapiens Q7Z6N9
Validated Y2H
32296183
Intra
DYNLL1 P63167 REDIC1 Homo sapiens Q86WS4
Y2H Prey Pooling
32296183
Intra
DYNLL1 P63167 REDIC1 Homo sapiens Q86WS4
Validated Y2H
32296183
Intra
DYNLL1 P63167 REDIC1 Homo sapiens Q86WS4
Y2H Array
32296183
Intra
DYNLL1 P63167 NEK9 Homo sapiens Q8TD19
TAP
27173435
Intra
DYNLL1 P63167 NEK9 Homo sapiens Q8TD19
Anti Tag CoIP
33961781
Intra
DYNLL1 P63167 NEK9 Homo sapiens Q8TD19
Anti Tag CoIP
26496610
Intra
DYNLL1 P63167 NEK9 Homo sapiens Q8TD19
Anti Tag CoIP
35271311
Intra
DYNLL1 P63167 SEPTIN4 Homo sapiens O43236
Validated Y2H
32296183
Intra
DYNLL1 P63167 PKIG Homo sapiens Q9Y2B9
Validated Y2H
32296183
Intra
DYNLL1 P63167 DYRK1A Homo sapiens Q13627
Anti Tag CoIP
35271311
Intra
DYNLL1 P63167 DYRK1A Homo sapiens Q13627
Anti Tag CoIP
33961781
Intra
DYNLL1 P63167 OTUD6A Homo sapiens Q7L8S5
Validated Y2H
32296183
Intra
DYNLL1 P63167 CIMAP1A Homo sapiens Q96PU9
Validated Y2H
32296183
Intra
DYNLL1 P63167 C19orf44 Homo sapiens Q9H6X5-2
Validated Y2H
32296183
Intra
DYNLL1 P63167 DPPA3 Homo sapiens Q6W0C5
Validated Y2H
32296183
Intra
DYNLL1 P63167 FAM53B Homo sapiens Q14153-2
Validated Y2H
32296183
Intra
DYNLL1 P63167 BACH1 Homo sapiens O14867
Anti Tag CoIP
35271311
Intra
DYNLL1 P63167 BACH1 Homo sapiens O14867
Anti Tag CoIP
33961781
Intra
DYNLL1 P63167 RASGRP4 Homo sapiens Q8TDF6-2
Validated Y2H
32296183
Intra
DYNLL1 P63167 ZNF710 Homo sapiens Q8N1W2
Validated Y2H
32296183
Intra
DYNLL1 P63167 ZNF710 Homo sapiens Q8N1W2
Y2H Prey Pooling
32296183
Intra
DYNLL1 P63167 ZNF710 Homo sapiens Q8N1W2
Y2H Array
32296183
Intra
DYNLL1 P63167 ZNF710 Homo sapiens Q8N1W2
Anti Tag CoIP
35271311
Intra
DYNLL1 P63167 GPHN Homo sapiens Q9NQX3
Anti Tag CoIP
33961781
Intra
DYNLL1 P63167 GPHN Homo sapiens Q9NQX3
TAP
27173435
Intra
DYNLL1 P63167 GPHN Homo sapiens Q9NQX3
Anti Tag CoIP
35271311
Intra
DYNLL1 P63167 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
32296183
Intra
DYNLL1 P63167 HMBOX1 Homo sapiens Q6NT76
Anti Tag CoIP
33961781
Intra
DYNLL1 P63167 MORC3 Homo sapiens Q14149
Anti Tag CoIP
35271311
Intra
DYNLL1 P63167 MORC3 Homo sapiens Q14149
Anti Tag CoIP
33961781
Intra
DYNLL1 P63167 MORC3 Homo sapiens Q14149
TAP
27173435
Intra
DYNLL1 P63167 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra
DYNLL1 P63167 KANK2 Homo sapiens Q63ZY3
Y2H Array
25416956
Intra
DYNLL1 P63167 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
DYNLL1 P63167 KANK2 Homo sapiens Q63ZY3
Anti Tag CoIP
33961781
Intra
DYNLL1 P63167 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
25416956
Intra
DYNLL1 P63167 KANK2 Homo sapiens Q63ZY3
Validated Y2H
25416956
Intra
DYNLL1 P63167 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
DYNLL1 P63167 KANK2 Homo sapiens Q63ZY3
Anti Tag CoIP
35271311
Intra
DYNLL1 P63167 FAM153A Homo sapiens Q9UHL3
Validated Y2H
32296183
Intra
DYNLL1 P63167 RACK1 Homo sapiens P63244
Anti Bait CoIP
18420585
Intra
DYNLL1 P63167 RACK1 Homo sapiens P63244
Anti Tag CoIP
18420585
Intra
DYNLL1 P63167 RACK1 Homo sapiens P63244
Density Sedimentation
18420585
Intra
DYNLL1 P63167 FAM117B Homo sapiens Q6P1L5
Anti Tag CoIP
33961781
Intra
DYNLL1 P63167 FAM117B Homo sapiens Q6P1L5
Y2H Prey Pooling
32296183
Intra
DYNLL1 P63167 FAM117B Homo sapiens Q6P1L5
TAP
27173435
Intra
DYNLL1 P63167 FAM117B Homo sapiens Q6P1L5
Anti Tag CoIP
26496610
Intra
DYNLL1 P63167 FAM117B Homo sapiens Q6P1L5
Validated Y2H
32296183
Intra
DYNLL1 P63167 FAM117B Homo sapiens Q6P1L5
Y2H Array
32296183
Intra
DYNLL1 P63167 FAM117B Homo sapiens Q6P1L5
Anti Tag CoIP
35271311
Intra
DYNLL1 P63167 BMF Homo sapiens Q96LC9
Validated Y2H
32296183
Intra
DYNLL1 P63167 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
DYNLL1 P63167 DNAL4 Homo sapiens O96015
Y2H Array
32296183
Intra
DYNLL1 P63167 DNAL4 Homo sapiens O96015
Y2H Prey Pooling
32296183
Intra
DYNLL1 P63167 DNAL4 Homo sapiens O96015
Anti Tag CoIP
33961781
Intra
DYNLL1 P63167 THAP10 Homo sapiens Q9P2Z0
Validated Y2H
32296183
Intra
DYNLL1 P63167 THAP10 Homo sapiens Q9P2Z0
Y2H Array
32296183
Intra
DYNLL1 P63167 THAP10 Homo sapiens Q9P2Z0
Y2H Prey Pooling
32296183
Intra
DYNLL1 P63167 GNL3L Homo sapiens Q9NVN8
Validated Y2H
32296183
Intra
DYNLL1 P63167 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
32296183
Intra
DYNLL1 P63167 DCTN5 Homo sapiens Q9BTE1
Validated Y2H
32296183
Intra
DYNLL1 P63167 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra
DYNLL1 P63167 SMCP Homo sapiens P49901
MAPPIT
32296183
Intra
DYNLL1 P63167 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
Intra
DYNLL1 P63167 SMCP Homo sapiens P49901
Y2H Array
32296183
Intra
DYNLL1 P63167 MYZAP Homo sapiens P0CAP1
Pull Down
20412299
Intra
DYNLL1 P63167 MYZAP Homo sapiens P0CAP1
Peptide Array
20412299
Intra
DYNLL1 P63167 IHO1 Homo sapiens Q8IYA8
Y2H Array
32296183
Intra
DYNLL1 P63167 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
25416956
Intra
DYNLL1 P63167 IHO1 Homo sapiens Q8IYA8
Validated Y2H
25416956
Intra
DYNLL1 P63167 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
32296183
Intra
DYNLL1 P63167 IHO1 Homo sapiens Q8IYA8
Validated Y2H
32296183
Intra
DYNLL1 P63167 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DYNLL1 Proteins

Cat. No. Product Name Accession Purity
HY-P70048 PIN/DYNLL1 Protein, Human (His) P63167 (M1-G89) ≥ 95%, as determined by reducing SDS-PAGE.

DYNLL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82979 DYNLL1 Antibody (YA2724) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat
HY-P82979A DYNLL1 Antibody (YA2724)(PBS only) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Rabies

  • Lyssa

  • Hydrophobia

  • St Hubert Disease
Prostate Carcinoma In Situ

  • Carcinoma In Situ Of Prostate

  • Grade Iii Pin

  • Pin Iii
Breast Adenoid Cystic Carcinoma

  • Adenoid Cystic Breast Carcinoma

  • Adenoid Cystic Carcinoma Of Breast

  • Mammary Adenocystic Carcinoma
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Asphyxiating Thoracic Dystrophy

  • Jeune Thoracic Dystrophy

  • Jeune Syndrome

  • Asphyxiating Thoracic Dysplasia

  • Short-Rib Thoracic Dysplasia With Or Without Polydactyly

  • Thoracic Pelvic Phalangeal Dystrophy

  • Asphyxiating Thoracic Chondrodystrophy

  • Atd

  • Chondroectodermal Dysplasia-Like Syndrome

  • Infantile Thoracic Dystrophy

  • Jeune Thoracic Dysplasia

  • Thoracic Asphyxiant Dystrophy

  • Thoracic-Pelvic-Phalangeal Dystrophy

  • Short-Rib Thoracic Dysplasia Without Polydactyly

  • Asphyxiating Thoracic Dystrophy Of The Newborn

  • Asphyxiating Thorax Dystrophy
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04088 DYNLL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19253 Dynll1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25742 Dynll1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DYNLL1 MGD MGI:1861457
Canis familiaris DYNLL1 VGNC VGNC:40150
Rattus norvegicus DYNLL1 RGD RGD:619866
Felis catus DYNLL1 VGNC VGNC:107702
Macaca mulatta DYNLL1 VGNC VGNC:99924
Others DYNLL1 NCBI