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THAP10 - THAP domain containing 10 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56906

About THAP10

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:70,881,342-70,892,433 (from NCBI)

This gene has 2 transcripts (splice variants), 169 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 3.1), thyroid (RPKM 2.1) and 24 other tissues.

Summary

This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast Cancer. [provided by RefSeq, Nov 2010]

THAP10 Products (1)

mRNA	Protein	Name
NM_020147.4	NP_064532.1	THAP domain-containing protein 10

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THAP10 Protein Structure

THAP

0
100
200
257 a.a.

Protein Preferred Names	Protein Names
THAP domain-containing protein 10

THAP10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	THAP10	Q9P2Z0	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	THAP10	Q9P2Z0	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	THAP10	Q9P2Z0	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	THAP10	Q9P2Z0	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	THAP10	Q9P2Z0	KRTAP10-5	Homo sapiens	P60370	Y2H Array	25416956
Intra	THAP10	Q9P2Z0	DYNLL1	Homo sapiens	P63167	Y2H Prey Pooling	32296183
Intra	THAP10	Q9P2Z0	DYNLL1	Homo sapiens	P63167	Y2H Array	32296183
Intra	THAP10	Q9P2Z0	PSME3	Homo sapiens	P61289	Y2H Array	32296183
Intra	THAP10	Q9P2Z0	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	32296183
Intra	THAP10	Q9P2Z0	PTS	Homo sapiens	Q03393	Y2H Array	25416956
Intra	THAP10	Q9P2Z0	PTS	Homo sapiens	Q03393	Validated Y2H	25416956
Intra	THAP10	Q9P2Z0	PTS	Homo sapiens	Q03393	Y2H Prey Pooling	25416956
Intra	THAP10	Q9P2Z0	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	THAP10	Q9P2Z0	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	THAP10	Q9P2Z0	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	THAP10	Q9P2Z0	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	THAP10	Q9P2Z0	CCNDBP1	Homo sapiens	O95273	Y2H Array	25416956
Intra	THAP10	Q9P2Z0	CCNDBP1	Homo sapiens	O95273	Y2H	21516116
Intra	THAP10	Q9P2Z0	CCNDBP1	Homo sapiens	O95273	Y2H Array	31515488
Intra	THAP10	Q9P2Z0	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	25416956
Intra	THAP10	Q9P2Z0	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14470	THAP10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown