MYZAP - myocardial zonula adherens protein Gene

Also Known as Gup; GCOM1; MYOZAP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 100820829

About MYZAP

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:57,591,904-57,685,364 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 3 paralogues. Biased expression in heart (RPKM 228.1), fat (RPKM 55.5) and 5 other tissues.

Summary

This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and the neighboring downstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) and is represented with GeneID: 145781. [provided by RefSeq, Mar 2014]

MYZAP Products (2)

mRNA Protein Name
NM_001018100.5 NP_001018110.1 myocardial zonula adherens protein isoform 1 precursor
NM_152451.8 NP_689664.3 myocardial zonula adherens protein isoform 2

MYZAP Protein Structure

GCOM2

GCOM2: Putative GRINL1B complex locus protein 2 (96 - 416)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 466 a.a.
Protein Preferred Names Protein Names

myocardial zonula adherens protein

  • GRINL1A complex locus upstream

MYZAP Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
MYZAP P0CAP1 DYNLL1 Homo sapiens P63167
Y2H
20412299
Intra
MYZAP P0CAP1 DYNLL1 Homo sapiens P63167
NMR
20412299
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08975 MYZAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus MYZAP MGD MGI:2142908
Bos taurus MYZAP VGNC VGNC:55127
Rattus norvegicus MYZAP RGD RGD:1359197
Others MYZAP NCBI