MYZAP - myocardial zonula adherens protein Gene

Homo sapiens

Also known as Gup; GCOM1; MYOZAP

Gene ID: 100820829 | Gene type: protein coding

About MYZAP

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:57,591,904-57,685,364 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 3 paralogues. Biased expression in heart (RPKM 228.1), fat (RPKM 55.5) and 5 other tissues.

Summary

This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and the neighboring downstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) and is represented with GeneID: 145781. [provided by RefSeq, Mar 2014]

MYZAP Products(2)

mRNA	Protein	Name
NM_001018100.5	NP_001018110.1	myocardial zonula adherens protein isoform 1 precursor
NM_152451.8	NP_689664.3	myocardial zonula adherens protein isoform 2

MYZAP Protein Structure

GCOM2

0
100
200
300
400
466 a.a.

Protein Preferred Names

Protein Names

myocardial zonula adherens protein

GRINL1A complex locus upstream

Related Diseases

Diseases

Alias

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08975	MYZAP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MYZAP	MGD	MGI:2142908
Bos taurus	MYZAP	VGNC	VGNC:55127
Rattus norvegicus	MYZAP	RGD	RGD:1359197

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