FBXL10 Antibody (YA4378)(PBS only)

Cat. No.: HY-P84681A: Data Sheet User Guide for Antibodies
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FBXL10 Antibody (YA4378) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to FBXL10.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명
References

제품 설명

FBXL10 Antibody (YA4378) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to FBXL10.

Host

Mouse

분자량

Predicted band size: 153 kDa;

Observed band size: 153 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q8NHM5

Gene ID

84678 [NCBI]

Immunogen

Purified recombinant fragment of human FBXL10 (AA: 457-555) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable)

Subcellular Localization：Nucleus, nucleolus; Nucleus; Chromosome

Isoforms & Post-Translational Modification：Q8NHM5 has 5 isomers: Q8NHM5-1: 152615 Da (predicted); Q8NHM5-2: 149034 Da (predicted); Q8NHM5-3: 151328 Da (predicted); Q8NHM5-4: 144769 Da (predicted); Q8NHM5-5: 63630 Da (predicted).

Subunit：Interacts with SKP1, forming heterodimers (PubMed:27568929). The heterodimeric KDM2B-SKP1 complex interacts with the PCGF1-BCORL1 heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (PubMed:27568929). Directly interacts with CUL1. The SKP1-KDM2B complex interacts with UBB (PubMed:30033217)

Synonyms

CXXC2; Fbl10; PCCX2; KDM2B; JHDM1B

각종 서류

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/ht-29-cell.html