KDM2B - lysine demethylase 2B Gene

Also Known as CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84678

About KDM2B

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,408,461-121,582,279 (from NCBI)

This gene has 18 transcripts (splice variants), 299 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 6.6), appendix (RPKM 5.9) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

KDM2B Products (2)

mRNA	Protein	Name
NM_001005366.2	NP_001005366.1	lysine-specific demethylase 2B isoform b
NM_032590.5	NP_115979.3	lysine-specific demethylase 2B isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone H3K36 demethylase activity	IDA IDA: Inferred from direct assay	26237645	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16943429	GOA
enables unmethylated CpG binding	IDA IDA: Inferred from direct assay	29276034	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	29276034	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	16943429	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of PcG protein complex	IDA IDA: Inferred from direct assay	16943429	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26237645	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM2B Protein Structure

Cupin_8

zf-CXXC

F-box

0
300
600
900
1200
1336 a.a.

Protein Preferred Names	Protein Names
lysine-specific demethylase 2B	CXXC-type zinc finger protein 2

KDM2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KDM2B	Q8NHM5	SKP1	Homo sapiens	P63208	TAP	24981860
Intra	KDM2B	Q8NHM5	SKP1	Homo sapiens	P63208	Anti Tag CoIP	33692209
Intra	KDM2B	Q8NHM5	BCOR	Homo sapiens	Q6W2J9	TAP	24981860
Intra	KDM2B	Q8NHM5	BCOR	Homo sapiens	Q6W2J9	Anti Tag CoIP	16943429

Cross: Cross-species interaction Intra: Intraspecies interaction

KDM2B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84681	FBXL10 Antibody (YA4378)	WB, FC, ELISA	Human
HY-P84681A	FBXL10 Antibody (YA4378)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic
Hypotonia
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Microphthalmia, Syndromic 2	Oculofaciocardiodental Syndrome Ofcd Syndrome MCOPS2 Microphthalmia, Cataracts, Radiculomegaly, And Septal Heart Defects Syndromic Microphthalmia 2 Anop2 Cataract-Microphthalmia-Radiculomegaly-Cardiac Septal Defect Syndrome Maa2 Microphthalmia Cataracts Radiculomegaly And Septal Heart Defects Syndromic Microphthalmia Type 2 Oculo-Facio-Cardio-Dental Syndrome Anop2, Formerly Maa2, Formerly Microphthalmia Syndromic 2 Oculo Facio Cardio Dental Syndrome Microphthalmia, Syndromic, 2 Marashi-Gorlin Syndrome Microphthalmia, Cataracts, Radiculomegaly And Septal Heart Defects Microphthalmia, Syndromic, Type 2
Arboleda-Tham Syndrome	Kat6a Syndrome Autosomal Dominant Intellectual Disability-Craniofacial Anomalies-Cardiac Defects Syndrome ARTHS Mrd32 Mental Retardation, Autosomal Dominant 32, Formerly Mrd32, Formerly Autosomal Dominant Mental Retardation 32 Autosomal Dominant Non-Syndromic Intellectual Disability 32 Arboleda-Tham
Armfield Syndrome	X-Linked Intellectual Disability, Armfield Type Armfield X-Linked Mental Retardation Syndrome Mental Retardation Syndrome, X-Linked, Armfield Type Mrxsa Syndromic X-Linked Mental Retardation Armfield Type
Syndromic Microphthalmia	Microphthalmia, Syndromic
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12
Microphthalmia, Syndromic 1	MCOPS1 Lenz Microphthalmia Syndrome Lenz Dysplasia Mcops4 Syndromic Microphthalmia 1 Lenz Microphthalmia Maa Microphthalmia Or Anophthalmos With Associated Anomalies Syndromic Microphthalmia Type 4 Microphthalmia, Syndromic 4 Microphthalmia, Syndromic 4, Formerly Mcops4, Formerly Anop1, Formerly Maa, Formerly Lenz Type Microphthalmia Syndromic Microphthalmia 4 Microphthalmia Lenz Type Microphthalmia Syndromic 1 Syndromic Microphthalmia Type 1 Microphthalmia Syndromic 4 Microphthalmia With Ankyloblepharon And Intellectual Disability Microphthalmia, Lenz Type Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome Microphthalmia, Syndromic, 1 Anop1 Microphthalmia, Syndromic, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129079	TFMB-(R)-2-HG	Inhibitor	98.26%	Unkown
HY-139561	KDM2B-IN-2		99.36%	Unkown
HY-139601	KDM2B-IN-4	Inhibitor	99.61%	Unkown
HY-139560	KDM2B-IN-1	Inhibitor	99.49%	Unkown
HY-RS07210	KDM2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-139600	KDM2B-IN-3	Inhibitor	/	Unkown
HY-RS16813	Kdm2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23253	Kdm2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KDM2B	VGNC	VGNC:30524
Rattus norvegicus	KDM2B	RGD	RGD:1310217
Mus musculus	KDM2B	MGD	MGI:1354737
Macaca mulatta	KDM2B	VGNC	VGNC:81425
Felis catus	KDM2B	VGNC	VGNC:80446
Canis familiaris	KDM2B	VGNC	VGNC:42321
Others	KDM2B	NCBI