FBXL10 Antibody (YA4378)
(Synonyms: CXXC2; Fbl10; PCCX2; KDM2B; JHDM1B)FBXL10 Antibody (YA4378) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to FBXL10.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
FBXL10 Antibody (YA4378) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to FBXL10.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 153 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 153 kDa
Purified recombinant fragment of human FBXL10 (AA: 457-555) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FBXL10 is a Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable)[1][2][3].
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Subcellular Localization
Nucleus, nucleolus; Nucleus; Chromosome
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Isoforms & Post-Translational Modification
Q8NHM5 has 5 isomers: Q8NHM5-1: 152615 Da (predicted); Q8NHM5-2: 149034 Da (predicted); Q8NHM5-3: 151328 Da (predicted); Q8NHM5-4: 144769 Da (predicted); Q8NHM5-5: 63630 Da (predicted).
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Subunit
Interacts with SKP1, forming heterodimers (PubMed:27568929). The heterodimeric KDM2B-SKP1 complex interacts with the PCGF1-BCORL1 heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (PubMed:27568929). Directly interacts with CUL1. The SKP1-KDM2B complex interacts with UBB (PubMed:30033217)
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SwissProt ID
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Synonyms
CXXC2; Fbl10; PCCX2; KDM2B; JHDM1B
Documentation
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