HNRNPA0 Antibody (YA6596)

Cat. No.: HY-P86903: Data Sheet User Guide for Antibodies
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HNRNPA0 Antibody (YA6596) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HNRNPA0.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

HNRNPA0 Antibody (YA6596) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HNRNPA0.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 31 kDa;

Observed band size: 34/36 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat, Monkey

SwissProt ID

Q13151

Gene ID

10949 [NCBI]

Immunogen

Recombinant protein within human HNRNPA0 aa 1-250 / 305.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000-1:5000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:2000
FC FC: Flow Cytometry	1:1000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：Q13151: 305 amino acids, molecular weight 30841 Da.
Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin丨Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation丨Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac)丨Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:12086618, PubMed:15964846, PubMed:17967882)丨Acetyl-methylated at Lys-6 and Lys-13 (H4K5acme and H4K12acme, respectively), acetyl-methylation is an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000)丨Phosphorylated by PAK2 at Ser-48 (H4S47ph)丨Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation丨Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage丨Sumoylated, which is associated with transcriptional repression丨Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells丨Butyrylation of histones marks active promoters and competes with histone acetylation丨Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes丨Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732)

Synonyms

Heterogeneous nuclear ribonucleoprotein A0 antibody; hnRNA binding protein antibody; hnRNP A0 antibody; HNRNPA0 antibody; HNRPA0 antibody; ROA0_HUMAN antibody;

Documentation

User Guide for Antibodies (1077 KB)