HNRNPA0 Antibody (YA6596)

Nucleus

Q13151: 305 amino acids, molecular weight 30841 Da.
Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin丨Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation丨Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac)丨Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:12086618, PubMed:15964846, PubMed:17967882)丨Acetyl-methylated at Lys-6 and Lys-13 (H4K5acme and H4K12acme, respectively), acetyl-methylation is an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000)丨Phosphorylated by PAK2 at Ser-48 (H4S47ph)丨Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation丨Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage丨Sumoylated, which is associated with transcriptional repression丨Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells丨Butyrylation of histones marks active promoters and competes with histone acetylation丨Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes丨Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732)

Q13151

Heterogeneous nuclear ribonucleoprotein A0 antibody; hnRNA binding protein antibody; hnRNP A0 antibody; HNRNPA0 antibody; HNRPA0 antibody; ROA0_HUMAN antibody;