ICAM-1/CD54 Antibody (YA9161)
(Synonyms: CD54, Icam-1, ICAM 1, Icam1, MALA-2)
Based on 1 Customer Validation
ICAM-1/CD54 Antibody (YA9161) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ICAM-1/CD54.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ICC/IF, IF-Tissue, IHC-P, FC
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Reactivity :
mouse, rat
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:50-500 | 1:50-500 | 1:100-500 | 1μg per 1*106 cells |
Product Details
ICAM-1/CD54 Antibody (YA9161) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ICAM-1/CD54.
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Host Mouse
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Species Reactivitymouse, rat
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Calculated Molecular Weight Predicted band size: 85-110 kDa
A synthesized peptide derived from rat IC ICAM-1/CD54.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
ICAM-1/CD54 is a Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells. -
Isoforms & Post-Translational Modification
ICAM-1/CD54 has 2 isoforms, P13597-1: amino acid length is 537, molecular weight is 58844 Da (predicted); P13597-2: amino acid length is 531, molecular weight is 58753 Da (predicted).Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis
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Subunit
Homodimer.
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SwissProt ID
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Synonyms
CD54, Icam-1, ICAM 1, Icam1, MALA-2
Documentation
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