KMT2C Antibody (YA4374)(PBS only)
(Synonyms: HALR; MLL3; KLEFS2)KMT2C Antibody (YA4374) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KMT2C.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
IHC-P, ICC/IF, FC, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
KMT2C Antibody (YA4374) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KMT2C.
-
Host Mouse
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 269 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 541 kDa
Purified recombinant fragment of human KMT2C (AA: 1-205) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
KMT2C is a Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements[1][2][3].
-
Subcellular Localization
Nucleus
-
Expression
Tissue_specificity:Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver -
Isoforms & Post-Translational Modification
Q8NEZ4 has 3 isomers: Q8NEZ4-1: 541370 Da (predicted); Q8NEZ4-2: 547117 Da (predicted); Q8NEZ4-3: 547633 Da (predicted).
-
Subunit
Component of the MLL3 complex (also named ASCOM complex), at least composed of catalytic subunit KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (PubMed:17021013, PubMed:17500065, PubMed:23508102). Forms a core complex with the evolutionary conserved subcomplex WRAD composed of WDR5, RBBP5, ASH2L/ASH2 and DPY30 subunits; WRAD differentially stimulates the methyltransferase activity (PubMed:25561738). Interacts (via WIN motif) with WDR5 (PubMed:22266653, PubMed:22665483)
-
SwissProt ID
-
Synonyms
HALR; MLL3; KLEFS2
Documentation
Powered by Bioz
