LRRC25 Antibody (YA8483)
(Synonyms: MAPA)LRRC25 Antibody (YA8483) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LRRC25.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
LRRC25 Antibody (YA8483) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LRRC25.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 33 kDa
Full length human recombinant protein of human LRRC25 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LRRC25 plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy. Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA[1].
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Subcellular Localization
Membrane,Cytoplasm
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Expression
Tissue_Specificity: Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus
Induction: Down-regulated in CD40-activated monocyte-derived dendritic cells -
Isoforms & Post-Translational Modification
Q8N386: 305 amino acids, molecular weight 33179 Da.
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Subunit
Interacts with RIGI (PubMed:29288164)
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SwissProt ID
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Synonyms
MAPA
Documentation
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