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  5. MAG Antibody (YA2458)

MAG Antibody (YA2458) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAG.

For research use only. We do not sell to patients.

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250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

MAG Antibody (YA2458) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAG.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 69 kDa;
Observed band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human MAG aa50-100/626.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:2000
FC
FC: Flow Cytometry
1:50-1:100
IP
IP: Immunoprecipitation
1:50
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Solution
Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Shipping

Shipping with blue ice.
Background
Function：Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity)
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Membrane raft
Expression：
Tissue_specificity:Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:6200494, PubMed:9495552) . Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494) . Detected in compact myelin (at protein level) (PubMed:6200494) . Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552)
Isoforms & Post-Translational Modification：P20916 has 3 isomers: P20916-1: 69069 Da (predicted); P20916-2: 63966 Da (predicted); P20916-3: 66224 Da (predicted).
N-glycosylated;Phosphorylated on tyrosine residues;Ubiquitinated, leading to proteasomal degradation
Subunit：Monomer and homodimer (By similarity). Interacts with RTN4R (PubMed:19052207).
Database

Entrez Gene: 4099 Human ; 17136 Mouse ; 29409 Rat

SwissProt: P20916 Human ; P20917 Mouse ; P07722 Rat

OMIM: 616680 Human

Research Field

Neuroscience
Synonyms
MAG; GMA; Myelin-associated glycoprotein; Siglec-4a
Documentation
User Guide for Antibodies (1077 KB)

MAG Antibody (YA2458) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MAG Antibody (YA2458)
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HY-P82713
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