MAG Antibody (YA2458)
(Synonyms: MAG; GMA; Myelin-associated glycoprotein; Siglec-4a)
Based on 1 Customer Validation
MAG Antibody (YA2458) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAG.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:50-1:100 | 1:50 |
Product Details
MAG Antibody (YA2458) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAG.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 69 kDa
Entrez Gene: 4099 Human ; 17136 Mouse ; 29409 Rat
SwissProt: P20916 Human ; P20917 Mouse ; P07722 Rat
OMIM: 616680 Human
A synthesized peptide derived from human MAG aa50-100/626.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MAG is an Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth. Inhibits axon outgrowth by binding to RTN4R. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Membrane raft
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Expression
Tissue_specificity:Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:6200494, PubMed:9495552) . Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494) . Detected in compact myelin (at protein level) (PubMed:6200494) . Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552) -
Isoforms & Post-Translational Modification
P20916 has 3 isomers: P20916-1: 69069 Da (predicted); P20916-2: 63966 Da (predicted); P20916-3: 66224 Da (predicted).
N-glycosylated;Phosphorylated on tyrosine residues;Ubiquitinated, leading to proteasomal degradation -
Subunit
Monomer and homodimer (By similarity). Interacts with RTN4R (PubMed:19052207).
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SwissProt ID
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Synonyms
MAG; GMA; Myelin-associated glycoprotein; Siglec-4a
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Research Field
Neuroscience
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