MAG - myelin associated glycoprotein Gene
Also Known as GMA; S-MAG; SPG75; SIGLEC4A; SIGLEC-4A
Species: Homo sapiens
About MAG
This gene has 8 transcripts (splice variants), 182 orthologues, 16 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 53.6) and ovary (RPKM 16.9).
Summary
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]
MAG Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001199216.2 | NP_001186145.1 | myelin-associated glycoprotein isoform c |
| NM_002361.4 | NP_002352.1 | myelin-associated glycoprotein isoform a precursor |
| NM_080600.3 | NP_542167.1 | myelin-associated glycoprotein isoform b precursor |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in compact myelin |
IDA
IDA: Inferred from direct assay
|
6200494 | GOA |
| located in myelin sheath |
IDA
IDA: Inferred from direct assay
|
6200494 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
26179919 | GOA |
MAG Protein Structure
C2-set_2: CD80-like C2-set immunoglobulin domain (141 - 223)
I-set: Immunoglobulin I-set domain (240 - 322)
Ig_2: Immunoglobulin domain (336 - 409)
- 0
- 100
- 200
- 300
- 400
- 500
- 626 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
myelin-associated glycoprotein |
|
Recombinant MAG Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70318 | MAG/Siglec-4a Protein, Human (HEK293, His) | P20916-1 (G20-P516) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73833 | MAG/Siglec-4a Protein, Human (HEK293, Fc) | P20916-1 (G20-P516) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78207 | MAG/Siglec-4a Protein, Human (Biotinylated, HEK293, His-Avi) | P20916-1 (G20-P516) | ≥ 95%, as determined by Bis-Tris PAGE. |
MAG Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82713 | MAG Antibody (YA2458) | WB, FC, IP | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Spastic Paraplegia 75, Autosomal Recessive |
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| Polyneuropathy |
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| Optic Neuritis |
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| Chronic Polyneuropathy |
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| Pelizaeus-Merzbacher Disease |
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| Osteosclerotic Myeloma |
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| Kearns-Sayre Syndrome |
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| Neurofibroma |
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| Autoimmune Peripheral Neuropathy |
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| Sensory Peripheral Neuropathy |
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| Waldenstroem'S Macroglobulinemia |
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| Demyelinating Polyneuropathy |
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| Niemann-Pick Disease, Type A |
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| Neuritis |
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| Autoimmune Neuropathy |
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| Asymmetric Motor Neuropathy |
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| Miller Fisher Syndrome |
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| Multiple Sclerosis |
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| Demyelinating Disease |
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| Niemann-Pick Disease |
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| Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
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| Polyradiculopathy |
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| Autoimmune Disease Of Peripheral Nervous System |
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| Mononeuropathy |
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| Autoimmune Optic Neuritis |
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| Mononeuritis Multiplex |
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| Plexopathy |
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| Balo Concentric Sclerosis |
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| Hereditary Neuropathies |
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| Motor Peripheral Neuropathy |
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| Mononeuritis Of Upper Limb And Mononeuritis Multiplex |
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| Monoclonal Gammopathy Of Uncertain Significance |
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| Motor Neuron Disease |
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| Neuropathy, Hereditary, With Liability To Pressure Palsies |
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| Blood Protein Disease |
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| Cerebral Lymphoma |
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| Charcot-Marie-Tooth Disease And Deafness |
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| Wallerian Degeneration |
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| Central Pontine Myelinolysis |
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| Acute Disseminated Encephalomyelitis |
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| Hypertrophic Neuropathy Of Dejerine-Sottas |
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| Charcot-Marie-Tooth Disease |
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| Lymphoplasmacytic Lymphoma |
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| Progressive Relapsing Multiple Sclerosis |
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| Charcot-Marie-Tooth Disease, Demyelinating, Type 1a |
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| Primary Progressive Multiple Sclerosis |
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| Schizophrenia |
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| Hypomyelinating Leukodystrophy |
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| Leukodystrophy, Hypomyelinating, 5 |
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| Plasma Protein Metabolism Disease |
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| Peripheral Nervous System Disease |
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| Autoimmune Disease Of Central Nervous System |
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| Metachromatic Leukodystrophy |
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| Dystonia |
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| Optic Nerve Disease |
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| Amyotrophic Lateral Sclerosis 1 |
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| Myeloma, Multiple |
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| Neuromuscular Disease |
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| Hereditary Spastic Paraplegia |
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| Nervous System Disease |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | MAG | VGNC | VGNC:42923 |
| Felis catus | MAG | VGNC | VGNC:68136 |
| Rattus norvegicus | MAG | RGD | RGD:3035 |
| Macaca mulatta | MAG | VGNC | VGNC:74475 |
| Bos taurus | MAG | VGNC | VGNC:31143 |
| Mus musculus | MAG | MGD | MGI:96912 |
| Others | MAG | NCBI |