P2RY8 Antibody (YA4358)(PBS only)
(Synonyms: P2Y8)P2RY8 Antibody (YA4358) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to P2RY8.
-
Host:
Mouse
-
Isotype:
IgG2a
-
Application:
IHC-P, ICC/IF, FC, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:100-1:500 | 1:200-1:400 | 1:10000 |
Product Details
P2RY8 Antibody (YA4358) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to P2RY8.
-
Host Mouse
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 36 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 40.6 kDa
Purified recombinant fragment of human P2RY8 (AA: extra mix) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG2a
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
P2RY8 is a G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs. In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed. In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma. Contributes to GNA13-dependent pathway that suppresses GC B cell growth[1][2][3].
-
Subcellular Localization
Cell membrane; Multi-pass membrane protein
-
Expression
Tissue_specificity:Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain (PubMed:11004484, PubMed:15466006) . Expressed in B cells and follicular helper T cells in germinal centers (at protein level) (PubMed:30842656)
Induction:Down-regulated during granulocytic differentiation -
SwissProt ID
-
Synonyms
P2Y8
Documentation
Powered by Bioz
